Fluorescent in situ hybridization Reagents
ABclonal Technology Phospho-JAK2-Y1007/1008 Rabbit pAb
This gene encodes a non-receptor tyrosine kinase involved in cytokine and growth factor signaling. The primary isoform contains a FERM domain for receptor association, an SH2 domain for STAT binding, a pseudokinase domain, and a C-terminal kinase domain. Cytokine binding activates the kinase, which then phosphorylates and activates STAT proteins. Growth factors like TGF-beta 1 also activate this kinase, influencing gene transcription. Mutations in this gene are linked to inflammatory diseases and cancers. It is a target of IL6, involved in immune response and inflammation. Disruption of the IL6/JAK2/STAT3 pathway leads to increased cellular proliferation and myeloproliferative neoplasms. A mutation in the pseudokinase domain causes constitutive activation, leading to hypersensitivity to cytokines. This gene and its pathway are therapeutic targets for inflammatory conditions. Alternative splicing produces multiple isoforms.
![ABclonal Technology [KO Validated] SOD2 Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000097506.jpg-250.jpg)
ABclonal Technology [KO Validated] SOD2 Rabbit pAb
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1.
Genscript Corporation ROR1 30-305Ig-likeFrizzled
ROR1 (Receptor tyrosine kinase-like orphan receptor 1) also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1) is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains highly related to those of the Trk-family receptor tyrosine kinases and by the extracellular Frizzled-like cysteine-rich domains and kringle domains which are common to receptors of the Wnt family members
Genscript Corporation ROR1 30-305Ig-likeFrizzled
ROR1 (Receptor tyrosine kinase-like orphan receptor 1) also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1) is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains highly related to those of the Trk-family receptor tyrosine kinases and by the extracellular Frizzled-like cysteine-rich domains and kringle domains which are common to receptors of the Wnt family members