General Clinical Chemistry Analyzers and Accessories
Abcam WAY-316606, 1MG
MW 448.5 Da, Purity >=98%. A secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC₅₀ = 0.65 μM). It blocks sFRP-1 from interacting with Wnt and thus increases Wnt signaling.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Kifunensine, class I alpha-mannosidase inhibitor, 1MG
MW 232.19 Da. Cell-permeable, potent, selective inhibitor of class I α-mannosidases. (IC₅₀ = 20-50 nM for mung bean α-1,2-mannosidase I). Alkaloid originally isolated from the actinomycete Kitasatosporia kifunense. Used to suppress Endoplasmic Reticulum-Associated Degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam YM-155, survivin inhibitor, 25MG
MW 443.3 Da, Purity >98%. Novel small molecule potent survivin suppressant. Inhibits survivin promoter activity (IC₅₀ = 0.54 nM) and down-regulates survivin in vitro and in vivo. Induces apoptosis in human tumor cell lines in vitro at 10 nM, with little effect on other IAP or Bcl-2 family members.
The product is subject to the following: Abcam Restricted Use Statement
Abcam OSMI-1, O-GlcNAc transferase (OGT) inhibitor, 25MG
MW 563.6 Da, Purity >98%. Potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor. Inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Indo x imod, Indoleamine 2,3-dio x ygenase (IDO) inhibitor, 1G
MW 218.25 Da, Purity >95%. Methylated tryptophan which acts as an Indoleamine 2,3-dioxygenase (IDO) inhibitor. Prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen 3-oxo-C6-DL-HSL
Chemical. CAS 76924-95-3. Formula C10H15NO4. MW 213.2. Synthetic. N-3-Oxohexanoyl-DL-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones AHL are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms. At increased populations of bacteria, localized higher concentrations of 3OC6-HSL, an endogenous ligand to transcriptional factor LuxR, leads to increased production of both the AHL synthase and proteins responsible for bioluminescence. Numerous other species of bacteria also employ 3OC6-HSL in cell-to-cell communication. An autoinducer of P. fischeri luciferase and a specfic genetic regulator that is unrelated to at least one of the enzyme systems that it induces.
Abcam SCR7 pyrazine, NHEJ inhibitor, 5MG
MW 332.4 Da, Purity >98%. Small molecule nonhomologous end-joining (NHEJ) inhibitor. SCR7 analog. Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Quizalofop-p
Chemical. CAS 94051-08-8. Formula C17H13CIN2O4. MW 344.75. Synthetic. Aryloxyphenoxypropionic herbicide. Used for the post-emergence control of annual and perennial grass weeds in various field crops. Mode of action is through inhibition of acetyl CoA carboxylase ACCase. Compound can be used as analytical reference material.
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