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Cayman Chemical PyrroloquInolIn quInon 10mg
A quinone with diverse biological activities; inhibits fibril formation by Aβ42 and mouse prion protein at 100 and 300 μM; stimulates cell proliferation, reduces glutamate-induced production of ROS, necrosis, and caspase-3 activity and increases activity of SOD, CAT, and GPX in neural stem and progenitor cells; inhibits LPS-induced production of NO and PGE2 and suppresses LPS-induced expression of various pro-inflammatory mediators in primary microglia; reduces Iba-1 expression in the cerebral cortex and hippocampal dentate gyrus in mice at 3 and 10 mg/kg; decreases the number of α-SMA-positive hepatic cells, collagen deposition, and hepatic hydroxyproline levels in a mouse model of liver fibrosis; decreases serum glucose and total cholesterol levels, increases brain SOD, CAT, and GPX activities, and decreases brain lipid hydroperoxide levels in mice with streptozotocin-induced diabetes
