DNA Vectors
Abcam pCambia0380 Plant Expression Vector
pCambia0380 Plant Expression Vector
The product is subject to the following: Abcam Restricted Use Statement
ANTIBODY DESIGN LABS PADL-100 IPHAGEMID VECTOR
pADL™-100 is a phagemid vector designed for high levels of display on the filamentous bacteriophage M13 or equivalent. This vector contains a PelB leader sequence followed by a full-length copy of the gene III sequence and a double-SfiI cloning site to introduce foreign polypeptides on the N-terminal side of the gene III protein. Expression of the fusion is under the tight control of a lac promoter. The presence of a strong RBS, a proteolysis-resistant linker without tags and the absence of amber stop codon all contribute to maximize display on pIII.
BIOHIPPO AAV-U6-shRNA(scramble)-CMV-Luciferase-P2A-EGFP-SV40-polyA
Recombinant adeno associated virus expressing shRNA (scramble) fused to Luciferase EGFP under the U6 CMV promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Vector Biolabs Wilms tumor 1 Adenovirus (Ad-WT1)
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors.
Vector Biolabs GFP expressing RGD fiber modified Adenovirus (Ad(RGD)-CMV-GFP)
Ad infection is initiated by recognition of the native Ad5 receptor, coxsackievirus-adenovirus receptor (CAR), on target cells by the carboxy-terminal portion (i.e., knob) of the fiber protein. Therefore the infection efficiency of adenovirus is very low for cells with low or no CAR receptors. Arg-Gly-Asp (RGD) motif was introduced in the surface-exposed loops of adenovirus fiber knob, this enables the adenovirus to bypass CAR and mediate cell entry via RGD binding integrins. So the RDG modified adenovirus can be used for "retargeting" cells that regular adenovirus doesn't work well. The infection effeciency of RDG modified adenovirus can be tens or hundreds of times higher than standard Ad5 in some cells, including human or mouse macrophages, T cells, synoviocytes, islet grafts, adipocytes, MEF, etc.This is a RGD modified replication-deficient adenovirus expressing eGFP under a CMV promoter.
Vector Biolabs G protein-coupled receptor kinase 5 Adenovirus (Ad-GRK5)
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first is the second messenger regulated kinases such as cAMP dependent protein kinase A and protein kinase C. The second is the G protein-coupled receptor kinases (GRKs). Six members of the GRK family have been identified to date. These include rhodopsin kinase (GRK 1), two forms of beta-adrenergic receptor kinase (GRK 2 or beta-ARK 1 and GRK 3 or beta-ARK 2), IT-11 (GRK 4), GRK 5 and GRK 6. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
BIOHIPPO AAV-CR-Cre-WPREs
Recombinant adeno associated virus expressing Cre under the CR promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Vector Biolabs AAV1 CMV-Null AAV (AAV1-Null)
This AAV serotype 2/1 virus (with Capsid from AAV1 and ITR from AAV2) has a CMV promoter with no transgene. It's used as control AAV.
Cayman Chemical RGD PeptIDtrIfluoROCTAte 10mg
A synthetic compound made up of the arginine-glycine-aspartate motif used to inhibit integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation; also can directly induce apoptosis by activating pro-caspase-3
IBA LifeSciences StrGat Acptr Vctr pENTRY-IBA51
StarGate Entry Vector is designed to insert the PCR product of a certain gene of interest (GOI) to generate a Donor Vector. StarGate cloning via the pENTRY-IBA vector provides a tool for the systematic and rapid screen of the best working expression conditions for a certain GOI, where nothing is known from literature. After initial pENTRY cloning, the GOI in the resulting Donor Vector can be easily transferred by a simple one-tube reaction into a multitude of expression vectors (Acceptor Vectors) providing different features.
Vector Biolabs complement component 1, q subcomponent, beta Adenovirus (Ad-C1q(beta))
The complement component proteins, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R, and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. Adipsin, also designated complement factor D, is a serine protease that cleaves complement factor B and may be involved in obesity. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the serum complement system.
Vector Biolabs Homeodomain interacting protein kinase 2 Adenovirus (Ad-HIPK2)
The homeodomain-interacting protein kinase (HIPK) family includes three members, HIPK1, HIPK2, and HIPK3. Each family member contains a conserved protein kinase domain as well as a separate domain, which interacts with homeoproteins. HIPK2 appears to act as a corepressor of homeodomain transcription factors, such as NK-3. Also, HIPK2 is regulated by ubiquitin-like modification via the covalent binding of SUMO-1. Subsequently, it is directed to nuclear bodies in vitro.