Nucleotides
Apexbio Technology LLC Digoxigenin-11-UTP 25ul (10 mM)
Digoxigenin-11-UTP is a modified nucleoside triphosphate used for labeling RNA probes It incorporates a digoxigenin label attached to uridine triphosphate (UTP) allowing it to be incorporated into RNA molecules during in vitro transcription reactions Digoxigenin is a non-radioactive label widely utilized in molecular biology experiments especially in situ hybridization (ISH) and Northern blotting RNA probes labeled with Digoxigenin-11-UTP exhibit high sensitivity and low background noise providing clear detection results Additionally the digoxigenin label binds specifically to anti-digoxigenin antibodies making the detection process both straightforward and highly efficient Digoxigenin-11-UTP serves as an essential tool for studying gene expression and RNA localization
Apexbio Technology LLC 5-hme-CTP 50ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Selleck Chemical LLC Uracil S4177-50mg
Uracil is one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical
Cayman Chemical FDAApproved Drugs Screeng 50uL
A potent inhibitor of E-selectin and ICAM-1 expression in HUVECs stimulated with TNF-a (IC50s 20 and 25 nM respectively)
Cayman Chemical NIcotInamIde 100mg
A non-selectve COX nhbtor (C50s 0 5 and 2 33 UM for human COX-1 and COX-2 respectvely) reduces carrageenan-nduced paw edema and ncreases latency to paw wthdrawal n the hot plate test n rats when admnstered usng a sustaned-release mplant
Cayman Chemical GnglIosID GD2 PolycLNal n 50uL
A metabolite of glucose a component of proteoglycans levels are increased in fibroblasts isolated from patients with ISSD or Salla disease
Cayman Chemical N6- 2-IsopentenyladenIn 1g
A cell-permeable triazine compound that inhibits the human E2 ubiquitin-conjugating enzyme Rad6B selectively docks to the Rad6B catalytic site inhibits Rad6B-induced histone H2A ubiquitination downregulates intracellularBcatenin induces G2/M arrest and apoptosis and inhibits proliferation and migration of metastatic human breast cancer cells
Cayman Chemical N6- 2-IsopentenyladenIn 500mg
An endogenous thyroxine metabolite that activates the trace amine-associated receptor 1 at nanomolar concentrations influences thyroid hormone actions including body temperature heart rate and cardiac output as well as balances lipid and glucose utilization
Cayman Chemical AdenosIn 5-dIphosphate 1g
19(R)-Hydroxylated prostaglandins occur in Ug/ml concentrations in the semen of certain mammalian species especially primates. In the case of humans the compounds are primarily of the PGE series and the hydroxyl stereochemistry is 15(S)19(R).{7578} 19(R)-Hydroxylated prostaglandins are also found in the seminal plasma of marsupials where F-type compounds of the 1 and 2-series predominate.{2390} The 15(R)-hydroxy epimer of these 19-hydroxylated prostaglandins is the inverse or “unnatural” isomer at C-15. The biological role of 19(R)-hydroxylated prostaglandins is not well established. In the F-series 19(R)-hydroxylation is associated with a significant loss of receptor-mediated biological activity in some assays.{1441}
Cayman Chemical N6-MethyladenosIn 500mg
An internal standard for the quantification of ( )-epigallocatechin gallate by GC- or LC-MS
Cayman Chemical BODIPY 630650X succInImID5mg
A triacylglycerol has been detected in human breast milk
Cayman Chemical NIcotInamIde N-oxIde 25g
A carbamate pesticide an AChE inhibitor (IC50 1 67 M for C gigas enzyme) decreases the number of P penetrans and M hapla per gram of alfalfa (M sativa) root when applied to seeds at 50 mg/ml toxic to citrus nematode (T semipenetrans) larvae at 50 and 100 g/ml inhibits plasma and brain AChE as well as liver glucose-6-phosphatase and succinic acid dehydrogenase and reduces body weight gain in rats at 2 1 and 3 5 mg/kg
Cayman Chemical N6 2IsopentenyladenosIn 250mg
An isomer of valpromide that has been marketed as an anxiolytic and sedative compound abolishes the activity of MIP synthase in human brain crude homogenates (Ki 0 18 mM) suppresses electrographic seizures in animal models of status epilepticus