Protein Labeling Reagents
Biotium Insulin(E2-E3), CF568 conjugate, 0.1mg/mL
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have
Biotium CD70(BU69), CF568 conjugate, 0.1mg/mL
This antibody recognizes a protein of 30 kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown toinhibit T cell proliferation induced by dendritic cells.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blu
Biotium CD28(C28/75), CF568 conjugate, 0.1mg/mL
Recognizes a glycoprotein of 44-88 kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
![eMolecules 2644752-87-2 | BP Fluor 430 Picolyl Azide | Broadpharm705.710 | C31H34F3N7O7S | 0.000 | CC1(C)C=C(CS(O)(=O)=O)c2cc3c(cc(=O)oc3cc2N1CCCCCC(=O)NCCC(=O)Nc1ccc(CN=[N+]=[N-])nc1)C(F)(F)F | 1mg | 599128599](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502468790.JPG-250.jpg)
eMolecules 2644752-87-2 | BP Fluor 430 Picolyl Azide | Broadpharm705.710 | C31H34F3N7O7S | 0.000 | CC1(C)C=C(CS(O)(=O)=O)c2cc3c(cc(=O)oc3cc2N1CCCCCC(=O)NCCC(=O)Nc1ccc(CN=[N+]=[N-])nc1)C(F)(F)F | 1mg | 599128599
BP Fluor 430 Picolyl Azide | Broadpharm | 2644752-87-2705.710 | C31H34F3N7O7S | 0.000 | CC1(C)C=C(CS(O)(=O)=O)c2cc3c(cc(=O)oc3cc2N1CCCCCC(=O)NCCC(=O)Nc1ccc(CN=[N+]=[N-])nc1)C(F)(F)F | 1mg | 599128599
Biolegend Purified anti-FITC MaxparR Rea
Purified anti-FITC (Maxpar Ready) [FIT-22]; Isotype: Mouse IgG1, λ; Apps: FC, CyTOF; Size: 100 μg
Echelon Biosciences Research Labs GloPIPs BODIPY TMR PI(3)P 50 ug
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate (PI(3)P) is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4.GloPIPs are labeled at the sn-1 position with BODIPY-FL (505/513), BODIPY-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested. This item is non returnable
LICOR IRDye 680RD NHS Ester (50 mg)
IRDye infrared dyes from LI-COR Biosciences are available for researchers developing applications using near-infrared (NIR) fluorescence. These unique dyes are used in a variety of NIR imaging applications including Western blotting, plate-based assays, protein arrays, tissue section imaging, and molecular activity measurements. Standard NHS ester chemistry is used to produce custom probes labeled with LI-COR IRDye infrared dyes. The NHS ester reactive group provides the functionality for labeling primary and secondary amines, such as lysine residues in proteins.
AnaSpec 5 - FITC | 3326-32-7 | MFCD00005063 | 1g
5 - FITC | MW: 389.382 | 3326-32-7 | MFCD00005063 | 1g
Biotium CD20(B9E9), CF488A conjugate, 0.1mg/mL
Recognizes a protein of 33-37 kDa, identified as CD20 (Workshop V; Code CD20.12). B9E9 recognizes extracellular domain of CD20. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, B cell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B cells and its cytoplasmic domains are differentia
Biotium Human Kappa Light Chain(KLC264), CF488A conjugate, 0.1mg/mL
This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can gi
Biotium 5(6)-CARBOXYRhodamine 110-C5-Maleimide (
CR110-C5-maleimide (full name: 5(6)-Carboxyrhodamine 110-C5-maleimide) is a maleimide derivative of the green fluorescent dye carboxyrhodamine 110. The dye has spectral properties (Ex/Em (MeOH) = 502/524 nm) similar to those of fluorescein (fluorescein-5-maleimide, for example), but the photostability of the dye is among the best of all green fluorescent dyes. Thus, the dye is a superior green fluorescent dye for labeling thiols. Properties: Orange red solid soluble in DMF or DMSO; Store at -20°C and protect from light, especially in solution; C31H30N4O6; MW: 554.59.
Medchemexpress LLC Apn-PEG36-tetrazine | 1997.30 g·mol⁻1 | C94H161N7O38 | 10 MG
APN-PEG36-tetrazine is a tetrazine-functionalized polyethylene glycol (PEG36) reagent for bioorthogonal click chemistry and antibody-drug conjugate (ADC) linker development. It undergoes inverse electron-demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) groups, enabling rapid conjugation in bioconjugation workflows. The reagent is supplied in small research quantities and should be stored protected from light under inert conditions.
- Tetrazine-functionalized PEG36 for iEDDA click reactions.
- Suitable for antibody-drug conjugate (ADC) linker synthesis and bioconjugation.
- Molecular weight approximately 1997.30 g·mol⁻1.
- Available in small vial sizes for research use (1 mg, 5 mg, 10 mg).
- Store at -20°C protected from light; in solvent store at -80°C for long-term stability.
Biotium CD74(LN-2), CF488A conjugate, 0.1mg/mL
This antibody recognizes a protein of ~35 kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma ( ).Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecti
Biotium PLGF(PLGF94), CF568 conjugate, 0.1mg/mL
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesio
AdipoGen Fluorescein didecanoate
Chemical. CAS 7389-09-5. Formula C40H48O7. MW 640.8. Fluorescein didecanoate is a non-fluorescent hydrophobic fluorescein derivative that can pass through the cell membrane whereupon intracellular esterases hydrolyze the didecanoate group producing the highly fluorescent product fluorescein. The fluorescein molecules accumulate in cells. Fluorescein didecanoate is a fluorogenic substrate for C10 esterase that generates green fluorescence upon esterase cleavage. Spectral Data lambdaEx 497nM, lambdaEm 516nm. Extinction coefficient 80000 cm-1 M-1.