Protein Labeling Reagents
AdipoGen Fluorescein didecanoate
Chemical. CAS 7389-09-5. Formula C40H48O7. MW 640.8. Fluorescein didecanoate is a non-fluorescent hydrophobic fluorescein derivative that can pass through the cell membrane whereupon intracellular esterases hydrolyze the didecanoate group producing the highly fluorescent product fluorescein. The fluorescein molecules accumulate in cells. Fluorescein didecanoate is a fluorogenic substrate for C10 esterase that generates green fluorescence upon esterase cleavage. Spectral Data lambdaEx 497nM, lambdaEm 516nm. Extinction coefficient 80000 cm-1 M-1.
Cayman Chemical AM694 3-Iodo Isomer 1mg
An analog of AM694; intended for forensic and research applications
Cayman Chemical AM1248 azepn Isomer 5mg
An analog of the synthetic cannabinoid AM1248; intended for forensic and research purposes
Revvity Health Sciences Inc IVISense 750 MAL Fluorescent Self-Quenching Dye (1 mg) (VivoTag)
IVISense 750 MAL Fluorescent Self-Quenching Dye (1 mg) (VivoTag)
Biotium CD117(C117/370), CF488A conjugate, 0.1mg/mL
CD117, also known as c-kit, is a member if the immunoglobin superfamily. It is a receptor tyrosine kinase that is expressed on hematopoietic progenitor cells. It binds to the c-kit ligand KITLG/SCF and has roles in cell survival and cell proliferation. Upon ligand binding, it activates a number of signaling pathways. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
eMolecules BP Fluor 568 Hydroxylamine | Broadpharm |766.840 | C36H38N4O11S2 | 0.000 | CC1(C)Nc2cc3Oc4cc5=NC(C)(C)C=C(CS(O)(=O)=O)c5cc4=C(c3cc2C(CS(O)(=O)=O)=C1)c1ccc(cc1C(O)=O)C(=O)NCCCON | 25mg | 599128671
BP Fluor 568 Hydroxylamine | Broadpharm |766.840 | C36H38N4O11S2 | 0.000 | CC1(C)Nc2cc3Oc4cc5=NC(C)(C)C=C(CS(O)(=O)=O)c5cc4=C(c3cc2C(CS(O)(=O)=O)=C1)c1ccc(cc1C(O)=O)C(=O)NCCCON | 25mg | 599128671
Biotium CD34(ICO-115), CF488A conjugate, 0.1mg/mL
This antibody recognizes a carbohydrate epitope on a single chain, transmembrane, heavily glycosylated protein of 90-120 kDa, which is identified as CD34 (VI international workshop on human differentiation antigens). Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi's sarcoma, but shows low specificity.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness
Biotium FOXP3(FXP3/197), CF568 conjugate, 0.1mg/mL
Recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.Primary antibodies are availabl
Medchemexpress LLC Mal-PEG10-NHS ester | 3055858-73-3 | 98.0% | 706.73 | 100 MG
Mal-PEG10-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins, connecting E3 ubiquitin ligase ligands with target protein ligands.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
eMolecules 1095667-71-2 | BP Fluor 350 Acid | Broadpharm313.280 | C12H11NO7S | 0.000 | Cc1c(CC(O)=O)c(=O)oc2cc(N)c(cc12)S(O)(=O)=O | 100mg | 599128560
BP Fluor 350 Acid | Broadpharm | 1095667-71-2313.280 | C12H11NO7S | 0.000 | Cc1c(CC(O)=O)c(=O)oc2cc(N)c(cc12)S(O)(=O)=O | 100mg | 599128560
Medchemexpress LLC Luc Yellow CH dilithium | 67769-47-5 | 99.7% | 10 MG
Luc Yellow CH dilithium is a high-intensity fluorescent probe containing free hydrazyl groups. It can react with fatty aldehydes at room temperature and serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Luc Yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively.
- Fluorescent dye
- Biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation
- Cell imaging/staining
- Used for Lucifer yellow CH (10 μg/mL; 12 h) staining images
- Used to evaluate GJ functionality
eMolecules 477876-64-5 | BP Fluor 532 NHS Ester | Broadpharm723.770 | C34H33N3O11S2 | 0.000 | CC1Nc2c(cc3C(c4ccc(cc4)C(=O)ON4C(=O)CCC4=O)=c4cc5c(=NC(C)C5(C)C)c(c4Oc3c2S(O)(=O)=O)S(O)(=O)=O)C1(C)C | 1mg | 599128630
BP Fluor 532 NHS Ester | Broadpharm | 477876-64-5723.770 | C34H33N3O11S2 | 0.000 | CC1Nc2c(cc3C(c4ccc(cc4)C(=O)ON4C(=O)CCC4=O)=c4cc5c(=NC(C)C5(C)C)c(c4Oc3c2S(O)(=O)=O)S(O)(=O)=O)C1(C)C | 1mg | 599128630
Cayman Chemical JWH 018 2-naphthyl Isomer 10mg
Differs structurally from JWH 018 by having the naphthyl group attached at the 2' position
Biotium Complement C4d(C4203), CF488A conjugate, 0.1mg/mL
This MAb is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, a
Biotium HCG-beta(HCGb/54), CF568 conjugate, 0.1mg/mL
This MAb reacts with a protein of 22 kDa, identified as β sub-unit of HCG. It does not cross react with the α sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.Primary antibodies are available purified, or with a selection of fluoresce