Protein Modification Reagents
Medchemexpress LLC M-PEG5-azide | 1202681-04-6 | 1 G
M-PEG5-azide is a PEG-based PROTAC linker crucial for the synthesis of PROTACs. This click chemistry reagent contains an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. It also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that have DBCO or BCN groups.
- Peg-based protac linker
- Used in protac synthesis
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC)
- Also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
Cayman Chemical dG-PEG 2000 250mg
A PEGylated derivative of DSG; LNPs containing DSG-mPEG(2000) and encapsulating an imidazoquinoline TLR7 and TLR8 agonist and a peptide antigen EAch conjugated to PGA increase the activation of dendritic cells, macrophages, and B cells in the draining lymph node and dendritic cells and B cells in the spleen in mice compared to the non-LNP-encapsulated PGA-conjugated TLR7/8 agonist and peptide antigen.
Medchemexpress LLC Propargyl-PEG4-5-nitrophenyl carbonate | 1422540-81-5 | 98.2% | 397.38 | 50 MG
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Exploits ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC Mal-PEG4-propargyl | 1262681-30-0 | 99.68% | 311.33 | 100 MG
Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. For research use only.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane | 55400-73-2 | 95.0% | 350.41 | 5 G
Ms-PEG4-MS is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for a target protein.
- PEG-based linker for PROTAC synthesis
- Facilitates targeted protein degradation via the ubiquitin-proteasome system
- Available in various quantities for research needs
Cayman Chemical PEG 2000-dPE 10mg
A PEGylated form of DSPE; has been used in the generation of micelles and in combination with other lipids in the formation of liposomes; liposomes containing DSPE-mPEG(2000) and encapsulating doxorubicin and quercetin reduce tumor growth in an MCF-7/adr multidrug-resistant breast cancer mouse xenograft model
Chemscene ChemScene | Boc-NH-PEG6-amine | 250MG | CS-0115431 | 0.97 | 1091627-77-8| MFCD16619391 | 424.53
ChemScene | Boc-NH-PEG6-amine | 250MG | CS-0115431 | 0.97 | 1091627-77-8| MFCD16619391 | 424.53
Chemscene ChemScene | Br-PEG4-C2-Boc | 250MG | CS-0107159 | 0.98 | 564476-32-0| MFCD22574808 | 385.29
ChemScene | Br-PEG4-C2-Boc | 250MG | CS-0107159 | 0.98 | 564476-32-0| MFCD22574808 | 385.29
Medchemexpress LLC S-acetyl-dPEG4-NHS ester | 937025-17-7 | MFCD11041102 | 98.0% | 421.46 g/mol | C17H27NO9S | 10 MG
S-acetyl-dPEG4-NHS ester is a discrete polyethylene glycol reagent that installs a protected thiol group via an N-hydroxysuccinimide (NHS) ester. It is used to thiolate proteins, peptides, and small molecules to enable downstream conjugation and crosslinking in bioconjugation and drug-delivery research. The reagent is supplied as a solid with reported purity and molecular weight.
- Protected thiol for controlled thiolation reactions.
- NHS-ester reactive group for efficient coupling to amines.
- Discrete PEG4 spacer improves solubility and reduces steric hindrance.
- Facilitates protein, peptide, and small-molecule conjugation.
- Suitable for bioconjugation and drug-delivery research workflows.
- Supplied as a stable solid suitable for storage and handling.
Medchemexpress LLC Propargyl-PEG4-5-nitrophenyl carbonate | 1422540-81-5 | 98.19% | 397.38 | 25 MG
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It acts as a click chemistry reagent, possessing an Alkyne group that enables it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs consist of two distinct ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, facilitating the selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups