Protein Modification Reagents
Cayman Chemical VH 032 LInker 6 10mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting Bcl-xL in senescent cells
STEMCELL Technologies Collagenase Type IV, Size: 100 mg
Collagenase is a protease consisting of a single polypeptide chain approximately 1,000 amino acid residues in length. Collagenase is capable of digesting native collagen fibrils commonly found in connective tissues and therefore is frequently used for tissue dissociation. Collagenase preparations contain the activity of several proteases, including collagenase, caseinase, clostripain, and trypsin (Kessler & Yaron). Collagenase Type IV contains low levels of tryptic activity and is frequently used for pancreatic islets (Taguchi et al.) and for applications where maintenance of receptor integrity is required.
Cayman Chemical PEG 2000-C-DMG 10mg
A PEGylated derivative of DMG; has been used in combination with other lipids in the formation of LNPs for the delivery of siRNA; LNPs containing C-DMG-mPEG(2000) and encapsulating siRNA targeting the genes encoding PD-L1 and PD-L2 decrease PD-L1 and PD-L2 levels in monocyte-derived dendritic cells
Cayman Chemical PEG 2000-C-DMG 5mg
A PEGylated derivative of DMG; has been used in combination with other lipids in the formation of LNPs for the delivery of siRNA; LNPs containing C-DMG-mPEG(2000) and encapsulating siRNA targeting the genes encoding PD-L1 and PD-L2 decrease PD-L1 and PD-L2 levels in monocyte-derived dendritic cells
Medchemexpress LLC t-Boc-N-amido-PEG5-Tos | 1404111-69-8 | MFCD34596623 | 96.0% | 491.60 | C22H37NO9S | 250 MG
t-Boc-N-amido-PEG5-Tos is a Boc-protected PEG5 linker bearing a tosyl leaving group. The hydrophilic PEG spacer improves solubility of conjugates, the tosyl enables efficient nucleophilic substitution, and the Boc group can be removed under mild acidic conditions to expose a primary amine. The reagent is intended for synthetic chemistry and bioconjugation applications.
- Hydrophilic PEG5 spacer improves aqueous solubility.
- Tosyl leaving group facilitates nucleophilic substitution.
- Boc-protected amine allows orthogonal deprotection strategies.
- Suitable for linker construction, bioconjugation, and PROTAC synthesis.
- Available in small research quantities for laboratory use.
Medchemexpress LLC DSPE-PEG-Folate | 1236288-25-7 | MFCD07107414 | 95.7% | 5000 | 5 MG
DSPE-PEG-Folate (MW 5000) is a PEGylated phospholipid in which DSPE is linked to a polyethylene glycol chain terminated with folic acid. It is designed to incorporate into liposomes or nanoparticle surfaces to present folate ligands for receptor-mediated targeting and uptake, and is used in targeted drug delivery, imaging, and nanoparticle functionalization in research settings.
- Facilitates folate-receptor mediated targeting.
- Integrates into lipid bilayers and can form micelles.
- Average molecular weight of 5000 for extended circulation properties.
- High purity (≈95.7%) suitable for research applications.
- Stable as a powder when stored at -20°C for long-term storage.
Medchemexpress LLC DSPE-PEG-SH | 90.0% | 10 MG
DSPE-PEG-SH (MW 1000) is a thiol-terminated pegylated phospholipid consisting of a DSPE hydrophobic anchor and a polyethylene glycol chain with an average molecular weight of 1000. It self-assembles into lipid bilayers and is commonly used to functionalize liposomes and lipid nanoparticles. The terminal thiol enables site-specific conjugation for attaching ligands, peptides, or probes, while the PEG chain imparts steric stabilization and improved circulation properties.
- Thiol terminal for site-specific conjugation.
- DSPE anchor for stable membrane incorporation.
- Pegylated chain for steric stabilization and reduced opsonization.
- Average molecular weight 1000 for short PEG spacer properties.
- Suitable for liposome and lipid nanoparticle functionalization.
Medchemexpress LLC m-PEG-DMG | 1019000-64-6 | 98.0% | 2000 Da (average) | (C2H4O)nC36H73NO5 | 100 MG
m-PEG-DMG (MW 2000) is a methoxy-terminated polyethylene glycol conjugated to dimyristoylglycerol. Supplied as a solid with an average molecular weight of about 2000 Da, it is formulated for preparation of PEGylated liposomes and lipid nanoparticles used in drug delivery research and related in vitro studies.
- High purity (98.0%).
- Average molecular weight ~2000 Da.
- White to off-white solid form.
- Suitable for liposome and lipid nanoparticle formulation.
- Provides steric stabilization and reduced protein opsonization.
- Available in small laboratory pack sizes (e.g., 5-100 mg).
- Documentation available: data sheet, COA, and SDS.
Medchemexpress LLC DBCO-PEG4-Val-Cit-PAB-PNP | 2226472-28-0 | 97.3% | 1079.16 | C55H66N8O15 | 50 MG
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker for bioconjugation and click-chemistry applications. It combines a dibenzocyclooctyne (DBCO) moiety for copper-free SPAAC conjugation with a PEG4 spacer for solubility and flexibility, a Val-Cit protease-cleavable dipeptide linked to a PAB self-immolative spacer, and a PNP leaving group for amine-mediated payload attachment.
- Contains DBCO for copper-free strain-promoted azide-alkyne cycloaddition.
- Includes PEG4 spacer to improve solubility and reduce steric hindrance.
- Features Val-Cit dipeptide cleavable by cathepsin B for selective payload release.
- Incorporates a PAB self-immolative spacer to enable rapid payload liberation after cleavage.
- Provides a PNP leaving group for straightforward amine coupling of payloads.
- Suited for synthesis of ADCs and conjugation to azide-bearing molecules.
Medchemexpress LLC DSPE-PEG-maleimide (MW 3400) ammonium | ≥95.0% | 3400 g/mol | (C2H4O)nC52H93N3NaO13P | 500 MG
DSPE-PEG-Maleimide (MW 3400) ammonium is a DSPE-based phospholipid conjugated to a polyethylene glycol chain (approx. 3.4 kDa) terminating in a maleimide reactive group. It is used to incorporate reactive PEGylated lipids into liposomes, nanostructured lipid carriers, and other nanoparticle systems to enable thiol-specific conjugation and improve colloidal stability.
Medchemexpress LLC DSPE-biotin | 133695-76-8 | MFCD34561787 | 97.5% | 974.36 | C51H96N3O10PS | 10 MG
DSPE-Biotin is a biotinylated phospholipid used to introduce biotin functionality into liposomes, lipid bilayers, and other lipid-based formulations for biochemical research and bioconjugation. It facilitates specific capture, labeling, and immobilization through high-affinity streptavidin/avidin interactions.
- Provides biotin functionality for liposomes and lipid bilayers.
- Enables high-affinity binding to streptavidin and avidin.
- Suitable for liposome formulation and surface immobilization applications.
- Soluble in DMSO; ultrasonic warming improves solubility.
- High purity for research use; handle and store protected from light.
- Stable when stored at -20°C for long-term storage.