Protein Modification Reagents
Medchemexpress LLC DBCO-PEG4-Val-Cit-PAB-PNP | 2226472-28-0 | 97.3% | 1079.16 | C55H66N8O15 | 5 MG
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker for research-scale conjugation. It features a DBCO click handle, a four-unit PEG spacer, a valine-citrulline protease-cleavable dipeptide, and a PAB/PNP leaving group to enable intracellular payload release after protease cleavage. Supplied as a solid for conjugation to azide-functionalized payloads and carriers.
- Contains DBCO click handle for strain-promoted azide-alkyne cycloaddition.
- Includes PEG4 spacer to increase hydrophilicity and reduce aggregation.
- Val-Cit dipeptide is cleavable by cathepsin B for intracellular payload release.
- PAB/PNP leaving group enables efficient payload release after cleavage.
- High purity suitable for research applications.
- Solid, off-white to light yellow appearance; store at -20°C and protect from light.
Medchemexpress LLC Biotin-PEG4-alkyne | 1458576-00-5 | MFCD22380755 | 99.7% | C21H35N3O6S | 10MG
Biotin-PEG4-alkyne is a biotin-labeled polyethylene glycol linker bearing a terminal alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAC). Supplied as a high-purity solid, it is intended for bioconjugation workflows, affinity capture and detection, and as a linker in targeted degradation (PROTAC) research.
- Terminal alkyne enables CuAAC click chemistry
- Biotin tag for affinity capture and detection
- PEG4 spacer improves solubility and reduces steric hindrance
- High purity for reproducible conjugation
- Available in small and bulk pack sizes for research needs
![eMolecules 2183473-14-3 | BDP FL-PEG4-amine TFA salt | Broadpharm510.390 | C24H37BF2N4O5 | 98.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCN)n1[B-]2(F)F | 100mg | 462125625](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203470.JPG-250.jpg)
eMolecules 2183473-14-3 | BDP FL-PEG4-amine TFA salt | Broadpharm510.390 | C24H37BF2N4O5 | 98.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCN)n1[B-]2(F)F | 100mg | 462125625
BDP FL-PEG4-amine TFA salt | Broadpharm | 2183473-14-3510.390 | C24H37BF2N4O5 | 98.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCN)n1[B-]2(F)F | 100mg | 462125625
Boston Bioproducts Inc PEG 8000 (30%) - 4x250ml
PEG 8000 (30%) - 4x250ml (For Research Use and Further Manufacturing Only)
Medchemexpress LLC DBCO-PEG8-NHS ester | 2553412-88-5 | 98.3% | C42H55N3O14 | 25 MG
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Functions as a click chemistry reagent
- Undergoes strain-promoted alkyne-azide cycloaddition
- Utilizes the ubiquitin-proteasome system for protein degradation
- Suitable for PROTAC synthesis
eMolecules 2512227-27-7 | Iodoacetamido-PEG3-NHS ester | Broadpharm486.259 | C15H23IN2O8 | 95.000 | ICC(=O)NCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 50mg | 784455349
Iodoacetamido-PEG3-NHS ester | Broadpharm | 2512227-27-7486.259 | C15H23IN2O8 | 95.000 | ICC(=O)NCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 50mg | 784455349
TARGETMOL CHEMICALS INC BIOTIN-PEG4-AZIDE 100MG
Also available in 25 mg 50 mg and bulk. Please contact Fisher for quotes. Biotin-PEG4-azide is a biotin-labeled PEG-based PROTAC linker that can be used in PROTAC synthesis. purity: 99%
Ambeed Fmoc-NH-PEG12-CH2CH2COOH | 1952360-91-6 | 840.0 g/mol |
Fmoc-NH-PEG12-CH2CH2COOH | 1952360-91-6 | 840.0 g/mol |
eMolecules 2550398-08-6 | Thalidomide-5-(PEG2-amine) | Broadpharm432.433 | C20H24N4O7 | 0.000 | NCCOCCOCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699639
Thalidomide-5-(PEG2-amine) | Broadpharm | 2550398-08-6432.433 | C20H24N4O7 | 0.000 | NCCOCCOCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699639
Medchemexpress LLC Amine-PEG-CH2COOH (MW 2000) | 139729-28-5 | 95.0% | 50 MG
Amine-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker primarily used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It is designed for research purposes and is not intended for patient use.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
Cayman Chemical BIOnT PROTAC FRGmnt lbrar 10mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
eMolecules 2639395-48-3 | DBCO-PEG2-DBCO | Broadpharm722.842 | C44H42N4O6 | 98.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCNC(=O)CCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 25mg | 591908421
DBCO-PEG2-DBCO | Broadpharm | 2639395-48-3722.842 | C44H42N4O6 | 98.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCNC(=O)CCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 25mg | 591908421
eMolecules m-PEG2-acid | Broadpharm | 149577-05-9 | MFCD09939037 | 148.158 | C6H12O4 | 98.000 | COCCOCCC(O)=O | 1g | 229582838
m-PEG2-acid | Broadpharm | 149577-05-9 | MFCD09939037 | 148.158 | C6H12O4 | 98.000 | COCCOCCC(O)=O | 1g | 229582838
![eMolecules 13-(Azide-PEG9-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |779.026 | C38H74N4O12 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 490840932](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502476876.JPG-250.jpg)
eMolecules 13-(Azide-PEG9-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |779.026 | C38H74N4O12 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 490840932
13-(Azide-PEG9-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |779.026 | C38H74N4O12 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 490840932
Medchemexpress LLC Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-[(4-oxo-8,11,14,17-tetraoxa-5-aza... | 1802907-98-7 | 95.0% | 653.63 g/mol | C29H39N3O14 | 50 MG
PC Alkyne-PEG4-NHS ester is a cleavable 4-unit PEG linker containing an alkyne group and an N-hydroxysuccinimide (NHS) ester, used for bioconjugation and click-chemistry applications such as antibody-drug conjugate synthesis.
- Cleavable 4-unit polyethylene glycol spacer for improved solubility.
- Alkyne functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- NHS ester reactive toward primary amines for efficient conjugation.
- Typical purity 95.0%.
- Storage: pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month).