Protein Modification Reagents
Medchemexpress LLC DSPE-PEG 2000 | 892144-24-0 | 99.37% | (C2H4O)nC42H82NO10P | 25 MG
DSPE-PEG 2000 is a PEG polymer containing DSPE and amine end groups. It can be used to form micelles as nanoparticles for drug delivery.
- Powder: -20°C for 3 years.
- In solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Biotin-PEG4-NHS ester | 459426-22-3 | 99.56% | C25H40N4O10S | 50 MG
Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker. It can be used in the synthesis of PROTACs for research purposes only.
- Biotin-labeled, PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC Amine-PEG3-desthiobiotin | 2237234-71-6 | None | 99.9% | 388.50 g·mol⁻¹ | C18H36N4O5 | 5 MG
Amine-PEG3-desthiobiotin is a short PEG-based linker with a terminal primary amine and a desthiobiotin affinity tag. It is designed for use in PROTAC synthesis and bioconjugation workflows where a removable biotin-like label and a short, flexible spacer are required.
- Provides a terminal primary amine for amide coupling.
- Contains a desthiobiotin tag for reversible affinity capture.
- Short PEG3 spacer reduces steric hindrance between ligands.
- High reported purity suitable for synthetic applications.
- Supplied as a solid for straightforward handling and storage.
- Compatible with common bioconjugation chemistries.
Medchemexpress LLC 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44-Pentadecaoxahexatetracontan-46-amine | 2745717-94-4 | 99.9% | 691.85 | 50 MG
The m-PEG15-amine is a chemical compound with the molecular formula C31H65NO15 and a molecular weight of 691.85. It is provided as a colorless to light yellow oil with a purity of 99.91%. This product is intended for use as a laboratory chemical and in the manufacture of substances. It is classified as hazardous, causing acute oral toxicity, skin and serious eye irritation, and potential respiratory tract irritation.
- Consistent with structure based on ¹H NMR Spectrum and LCMS
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
Medchemexpress LLC Rhodamine B PEG2-NH2 | 95.3% | 566.13 | 50 MG
Rhodamine B PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- Other ligand for the target protein
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG4-methyltetrazine | 1962919-31-8 | 95.3% | 674.81 g·mol⁻¹ | C31H46N8O7S | 10 MG
Biotin-PEG4-MeTz is a biotinylated click-chemistry reagent containing a terminal methyltetrazine that reacts rapidly with trans-cyclooctene via inverse electron-demand Diels-Alder (iEDDA) chemistry. Supplied as a solid, it is intended for preparation of biotinylated conjugates and labeling applications in chemical biology and bioconjugation workflows.
- Contains a terminal methyltetrazine for rapid iEDDA reactions.
- Includes a PEG4 spacer to improve solubility and reduce steric hindrance.
- Facilitates preparation of biotinylated conjugates and biomolecule labeling.
- Purple to purplish red solid; high purity (~95.3%).
- Soluble in DMSO at about 250 mg/mL; ultrasonication recommended.
- Store sealed at -20 °C away from moisture and light; in solution store at -80 °C for long term.
Medchemexpress LLC Mal-PEG4-C2-NH2 (TFA) | 2512227-13-1 | 98.6% | 430.37 | 100 MG
Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These compounds utilize the ubiquitin-proteasome system to selectively degrade target proteins, making them valuable laboratory chemicals for substance manufacturing.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 50 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules composed of two different ligands connected by a linker, where one ligand binds to an E3 ubiquitin ligase and the other to a target protein. These molecules leverage the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Composed of two different ligands connected by a linker
- Binds to an E3 ubiquitin ligase and a target protein
- Leverages the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
Medchemexpress LLC Bis-mal-lysine-peg4-tfp ester | 1426164-53-5 | 98.0% | C37H45F4N5O13 | 50 MG
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They consist of two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Consists of two different ligands connected by a linker
- Ligand binds to an E3 ubiquitin ligase
- Ligand binds to the target protein
Medchemexpress LLC Biotin-PEG11-Mal | 1646619-56-8 | 96.5% | C41H71N5O16S | 50 MG
Biotin-PEG11-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Utilizes E3 ubiquitin ligase and target protein ligands
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 100 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other for the target protein, enabling PROTACs to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC DSPE-PEG2000-Maleimide | 474922-22-0 | 99.58% | (C2H4O)x-C53H95NO14PNa | 100 MG
DSPE-PEG2000-Maleimide is a phospholipid-PEG conjugate that utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. It covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. It is for research use only and not sold to patients.
- Utilizes DSPE amphiphilicity for lipid bilayer insertion
- Covalently couples to sulfhydryl (-SH) of ligands
- Enables targeting capabilities for particles
- Used in research for breast cancer, lymphoma, and inherited retinal degeneration
- Used to prepare targeted liposomes (TLPD)
Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 50 MG
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring an azide group. It can engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups, and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent with an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC 3,6,9,15,18,21-Hexaoxa-12-azatricosane-1,23-diol | 63721-14-2 | 98.0% | C16H35NO8 | 50MG
NH-bis-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed with two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for a target protein. They leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mal-amido-PEG5-C2-NHS ester | 1315355-92-0 | >=98.0% | 557.55 g/mol | C24H35N3O12 | 1 G
Mal-amido-PEG5-C2-NHS ester is a non-cleavable PEG-based linker containing a maleimide and an N-hydroxysuccinimide (NHS) ester for conjugation to thiol and amine groups in proteins, peptides, and oligonucleotides. It is commonly used in antibody-drug conjugate (ADC) synthesis and other bioconjugation research applications.
- Contains maleimide and NHS ester functional groups
- Non-cleavable PEG-based linker for bioconjugation
- CAS number 1315355-92-0
- Molecular weight 557.55 g/mol
- Formula C24H35N3O12
- Appearance viscous liquid, colorless to light yellow
- Purity >=98.0%
- Storage pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month)
- Available in 1 G package