Protein Modification Reagents
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | >=97.0% | 290.31 | 50 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. PROTACs themselves consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest, enabling selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups
- Enables selective degradation of target proteins
Broadpharm NHS ESTER-PEG4-VAL-CIT-PAB-MMAE | MFCD34178780 | 10MG
NHS ESTER-PEG4-VAL-CIT-PAB-MMAE | MFCD34178780 | 10MG
Medchemexpress LLC T-Boc-N-amido-PEG5-tosylate | 1404111-69-8 | MFCD34596623 | 96.0% | 491.60 g/mol | C22H37NO9S | 1 G
A Boc-protected PEG5 tosyl linker for chemical conjugation and linker assembly. The reagent combines a hydrophilic five-unit polyethylene glycol spacer with a tosylate leaving group and a Boc-protected amine, providing improved solubility and enabling nucleophilic substitution for installation of PEG-based linkers in medicinal chemistry and bioconjugation workflows.
- Enhances aqueous solubility via PEG5 spacer.
- Enables nucleophilic substitution through tosylate leaving group.
- Protects primary amine with Boc for selective deprotection.
- Suitable for linker assembly and bioconjugation chemistry.
- Compatible with standard organic synthesis conditions.
AXISPHARM Cyanine5.5 DBCO | 2643308-61-4 | 1029.1 g/mol |
Cyanine5.5 DBCO | 2643308-61-4 | 1029.1 g/mol |
Medchemexpress LLC (2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy | 2010159-57-4 | 95.6% | 663.83 g/mol | C32H49N5O8S | 10 MG
(S,R,S)-AHPC-PEG4-NH2 is a VHL E3 ligase ligand-linker conjugate used as a building block in proteolysis-targeting chimera (PROTAC) synthesis. It couples an (S,R,S)-AHPC-derived VHL ligand to a four-unit polyethylene glycol (PEG4) linker terminating in a primary amine, providing a conjugation handle for attachment to target ligands.
- VHL E3 ligase ligand-linker conjugate for PROTAC assembly
- PEG4 linker with terminal primary amine for straightforward conjugation
- Molecular weight 663.83 g/mol
- Typical purity 95.6%; select batches up to 99.51%
- Highly soluble in DMSO (170 mg/mL); ultrasonic agitation recommended
- Powder storage: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (2 years)
Biotium Insulin(E2-E3), CF594 conjugate, 0.1mg/mL
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have
Supply Solutions Roche - Collagenase D, 100mg; from Clostridium histolyticum; pkg of 100 mg (11088858001) pkg of 2.5 g (11088882001) pkg of 500 mg (11088866001)
Roche - Collagenase D, 100mg; from Clostridium histolyticum; pkg of 100 mg (11088858001) pkg of 2.5 g (11088882001) pkg of 500 mg (11088866001)