Immunohistochemistry Kits and Reagents
Sino Biological Recombinant Human Cadherin-16 Protein (His Tag), Biotinylated 20 µg
A DNA sequence encoding the Human Cadherin-16 (NP_004053.1) (Met1-Ala786) was expressed with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
ABclonal Technology KO Validated Claudin 1
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet with complementary grooves in the inwardly facing extracytoplasmic leaflet The protein encoded by this gene a member of the claudin family is an integral membrane protein and a component of tight junction strands Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome
Biocare Medical, LLC intelliPATH FLX Peroxidase Blocking Reagent - 100 ml
Peroxidazed Blocking Reagent is a highly stable form of hydrogen peroxide for blocking endogenous peroxidase. It is very effective for blocking non-specific staining in red blood cells. It is non-flammable, safer and less toxic when compared to hydrogen peroxide/methanol formulations.
Revvity Health Sciences Inc AlphaLISA SureFire Ultra Multiplex Phospho-DAP12 (Tyr91 & total) Detection Kit, 500 Assay Points
AlphaLISA SureFire Ultra Multiplex Phospho-DAP12 (Tyr91 & total) Detection Kit, 500 Assay Points
Revvity Health Sciences Inc AlphaLISA SureFire Ultra Human Total p16 INK4A Detection Kit, 50,000 Assay Points
AlphaLISA SureFire Ultra Human Total p16 INK4A Detection Kit, 50,000 Assay Points
Medchemexpress LLC CDH16 Human HEK293 50ug
CDH16 a calcium-dependent cell adhesion protein belongs to the cadherin family It exhibits homophilic interactions potentially contributing to cell-type sorting and regulating cell-cell adhesions for cellular organization CDH16 Protein Human (HEK293 His) is the recombinant human-derived CDH16 protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC Discoidin domain receptor 1 (DDR1), rat recombinant protein (HEK293, His-tag) | >95.0% | 500 UG
Recombinant rat discoidin domain receptor 1 (DDR1) expressed in HEK293 cells with a C-terminal His tag. This purified protein is designed for biochemical and cell-based studies of collagen-mediated signaling, matrix remodeling, and protein-protein interactions. Purity is reported as greater than 95% by reducing SDS-PAGE, and multiple size formats are available, including a 500 μg option.
- HEK293-expressed rat DDR1 with C-terminal His tag.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Available in multiple sizes, including a 500 μg format.
- Suitable for biochemical and cell-based assays.
- Useful for studying collagen-mediated signaling, matrix remodeling, and receptor interactions.
Biotium CD74(BU45), CF594 conjugate, 0.1mg/mL
Recognizes proteins of 33, 35 and 41 kDa, which are identified as various isoforms of CD74. Its epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has b
Biotium CD86(BU63), CF594 conjugate, 0.1mg/mL
Recognizes a protein of 70 kDa, which is identified as CD86. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4, a cancer immunotherapy target. It is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. N
ABclonal Technology 488 Conjugated AIF1/IBA1
Enables actin filament binding activity and calcium ion binding activity Involved in several processes including Rac protein signal transduction actin filament organization and ruffle assembly Acts upstream of or within actin filament bundle assembly Located in several cellular components including actin filament phagocytic cup and ruffle membrane Is expressed in adrenal cortex central nervous system embryo mesenchyme and retina Human ortholog(s) of this gene implicated in type 1 diabetes mellitus Orthologous to human AIF1 (allograft inflammatory factor 1)
Biotium Human IgM Immunoglobulin(IM373), CF594 conjugate, 0.1mg/mL
Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
ABclonal Technology Phospho-p38 MAPK-T180/Y182
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes including cell proliferation differentiation transcriptional regulation and development The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs) Alternative splicing results in multiple transcript variants [provided by RefSeq Mar 2014]
Biotium Human Kappa Light Chain(L1C1), CF594 conjugate, 0.1mg/mL
This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can gi
Biotium CD34(ICO-115), CF594 conjugate, 0.1mg/mL
This antibody recognizes a carbohydrate epitope on a single chain, transmembrane, heavily glycosylated protein of 90-120 kDa, which is identified as CD34 (VI international workshop on human differentiation antigens). Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi's sarcoma, but shows low specificity.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness
Biotium FOXP3(FXP3/197), CF594 conjugate, 0.1mg/mL
Recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.Primary antibodies are availabl