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Fully sequenced samples of complimentary DNA synthesized from single-stranded, mammalian RNA. Various gene inserts sourced from humans, mice, monkeys, and other species are available. Ideal for use in gene cloning, as gene probes, and in cDNA library creation.
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This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
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A DNA sequence encoding the Cynomolgus/Rhesus TNFSF15 (F6S8F9) (Leu72-Leu251) was expressed, with a polyhistidine tag at the N-terminus. This construct has a trimer design. The purified protein was biotinylated in vitro.
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Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions A high resolution map of the binding site on human IgG1 for human Fc gamma RI Fc gamma RIIA Fc gamma RIIB Fc gamma RIIIA and FcRn receptors has been determined A common set of IgG1 residues is involved in binding to all Fc gamma R Fc gamma RII and Fc gamma RIII also utilize residues outside this common set
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This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas.
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