Protein Resins
AdipoGen MFAP4 human rec
Protein. Human MFAP4 aa 1-255 is fused at the C-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. Microfibril-associated protein 4 MFAP4 was initially identified as a gene commonly deleted in the contiguous Smith-Magenis syndrome SMS gene. MFAP4 was identified as growth factor to support expansion of hematopoietic stem cells in culture. It is involved in calcium-dependent cell adhesion and intercellular interactions.
Revvity Health Sciences Inc Membrane Target Systems: MCH 1 / SLC1 (human) membrane in CHO-K1 cells, 400 Units
Membrane Target Systems: MCH 1 / SLC1 (human) membrane in CHO-K1 cells, 400 Units
AdipoGen Fc humanFGL1 human rec
Recombinant Protein. Human FGL1 aa 23-312 is fused at the N-terminus to the Fc portion of human IgG1 and at the C-terminus to a His-Tag. Should activate human LAG-3 activity test not yet performed. Source/Host HEK 293 cells. Endotoxin <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. FGL1 Fibrinogen-like protein 1 also called Hepatocyte-derived fibrinogen-related protein 1 HFREP-1 or Hepassocin was initially identified as an overexpressed transcript in hepatocyte carcinoma and as a transcript enriched in regenerating liver. FGL1 is expressed at lower levels in brown and white adipose in the setting of liver injury. A low level expression of FGL1 is also observed in the pancreas. FGL1 is a 34 kDa protein structurally similar to Angiopoietin-like factors 2, 3, 4 and 6, which regulate lipid metabolism and energy utilization.
AdipoGen izTRAIL Soluble h rec
Protein. The extracellular domain of human TRAIL aa 95-281 is fused at the N-terminus to an isoleucine zipper motif. Source E. coli. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains 20mM TRIS-Cl, 0.5M arginine-HCl, 100mM NaCl, 0.02% Tween 20. Binds to human TRAIL receptors 1-4 TRAIL-R1 to TRAIL-R4 izTRAIL does not interact with the apoptosis-inducing mouse TRAIL receptor TRAIL-R. Purity >95% SDS-PAGE. izTRAIL is a newly available, highly active recombinant form of soluble human TRAIL. Due to a trimerizing N-terminal isoleucine zipper iz motif the intrinsic trimerization of TRAIL, required for apoptosis-inducing activity of TRAIL, is enhanced when compared to non-tagged soluble human TRAIL shTRAIL. Therefore, izTRAIL is a potent inducer of apoptosis in many human cancer cells, but not normal human hepatocytes. In addition, the half-life of izTRAIL is about eight-fold higher than the half-life of shTRAIL.
AdipoGen Progranulin rat rec
Protein. Signal peptide and rat progranulin aa 1-602 are fused at the C-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >95% SDS-PAGE. Progranulin PGRN is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration FTLD. In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease AD and potentially for MCI Mild Cognitive Impairment. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Sigma Aldrich Fine Chemicals Biosciences HiScreenTM MabSelectTM SuR
HiScreen(TM) MabSelect(TM) SuRe(TM) is prepacked with MabSelect(TM) SuRe(TM) and is part of the process development platform available from Cytiva. The columns are an excellent choice for method optimization and parameter screening for capture of monoclonal antibodies (MAbs).
Sigma Aldrich Fine Chemicals Biosciences MabSelectTM SuReTM Cytiva
MabSelect(TM) SuRe(TM) is a protein A affinity medium for capturing MAbs at process scale. MabSelect(TM) SuRe(TM) has an alkali-tolerant rProtein A ligand that allows the use of rigorous and cost-effective CIP and sanitization protocols based on 0.1 to 0.5 M NaOH. Further the ligand is protease stable leading to lower ligand leakage.MabSelect(TM) SuRe(TM) is a member of the MabSelect(TM) family of affinity chromatography media for the capture of monoclonal antibodies (MAbs) at process scale. MabSelect(TM) SuRe(TM) shares features and benefits of MabSelect(TM) such as a rigid high-flow agarose matrix that ensures excellent pressure/flow properties low non-specific binding that leads to low impurity levels in the eluate pool and an oriented ligand coupling for optimal binding capacity. In addition MabSelect(TM) SuRe(TM) features an alkali-tolerant rProtein A ligand. This ligand provides greater stability than conventional protein A-based media in the alkaline conditions used in clea
Sigma Aldrich Fine Chemicals Biosciences HiTrapR MabSelectTM PrismA
These HiTrap columns are prepacked with MabSelect PrismA protein A chromatography resin. This affinity resin in the packed column has been improved with an optimized high-flow agarose base matrix and a genetically engineered protein ligand allowing efficient cleaning between monoclonal antibody purification runs. This allows future demands in monoclonal antibody purification to be met including processing of many bispecific antibodies.Enhanced dynamic binding capacity compared with other protein A resins.Excellent alkaline stability enables efficient cleaning and sanitization using 0.5-1.0 M NaOH.Convenient HiTrap format for easy connection to a syringe peristaltic pump or chromatography systems such as an A„KTA system for convenient process optimization.The enhanced alkaline stability of MabSelect PrismA also provides opportunities for more robust mAb purification using periodic counter-current chromatography. The possibility for cleaning using 1 M NaOH increases bi
Cayman Chemical compre KInase ScreenIn 50uL
A mixture of farnesene isomers may contain trans-b-farnesene cis-a-farnesene trans-a-farnesene and bisabolene among others
AdipoGen ANGPTL4 mouse rec
Protein. Mouse ANGPTL4 aa 1-410 is fused at the C-terminus to a FLAG -tag. Source COS-7 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. ANGPTL4 Angiopoietin-like protein 4 mainly expressed in endothelial cells hypoxia-induced. Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain FLD. Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase LPL converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions.