Protein Purification Reagents and Kits
Medchemexpress LLC PROTAC B-Raf degrader 1 | 2364367-27-9 | 99.8% | 763.77 | 1 MG
PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity.
- Can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system.
- Affects the expression of Mcl-1, a downstream protein of B-Raf.
- Induces apoptosis in MCF-7 cells, with an apoptosis rate of 76.70% (64.00% early apoptosis, 12.70% late apoptosis) after 24 h incubation at 20 μM.
- Arrests cell cycle at the G2/M phase.
Medchemexpress LLC RAS/RAS-RAF-IN-1 | 2447039-81-6 | 99.8% | 807.98 | 1 MG
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor that exhibits antitumor activity. It demonstrates a KD of 5.0 μM-15 μM for cyclophilin A (CYPA) binding affinity. This compound is intended for research use only.
- Potent RAS and RAS-RAF inhibitor
- Exhibits antitumor activity
- Has a KD of 5.0 μM-15 μM for cyclophilin A (CYPA) binding affinity
- Shows EC50 of 0.5 μM-5.0 μM for BRAF-GTP-KRAS-G12C disruption in H358 cells
- Demonstrates IC50 of 1.0 μM-10 μM for pERK inhibition in H358 cells
- For research use only
American Research Products Inc Fish Glutathione PeroXidase G
Fish Glutathione PeroXidase (GSH-PX) ELISA kit from CUSABIO Detection Range 375 U/mL-6000 U/mL Sensitivity 187 5 U/mL Sample serum plasma tissue homogenates Method Competitive
ABclonal Technology Phospho-B-Raf-S445 Rabbit pAb
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.
AdipoGen FGF-23 msFc hrec
Recombinant protein. Mouse FGF-23 aa25-251 is fused at the C-terminus to the Fc portion of human IgG1. Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells. Source/Host HEK 293 cells. Purity >90% SDS-PAGE. Lyophilized. Contains PBS. FGF-23 Fibroblast growth factor 23 is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets ADHR and of hyperphosphatemic familial tumoral calcinosis HFTC.
Bioss KD-Validated Glutathione synth
Glutathione Synthetase Primary Antibody Unconjugated Public Immunogen Range 321-400/474 Host Species Rabbit Target Species Human Mouse Rat Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
Genscript Corporation Glutathione MagBeads
The GenScript Glutathione MagBeads are developed for quick and efficient small scale purification of recombinant glutathione S transferase (GST)-tagged fusion proteins from bacteria yeast and mammalian crude cell lysates
American Research Products Inc CELL GLUTATHIONE PEROXIDASE GP
5000265387 CELL GLUTATHIONE PEROXIDASE GP
BIOHIPPO Anti-Human BRAF/B-Raf Antibody (SAA1756), 100 µg
BRAF/B-Raf Recombinant Antibody (clone SAA1756) is a recombinant Mouse IgG2a, kappa antibody specific for BRAF/B-Raf. It reacts with Human. Suitable for ELISA. Recombinant production ensures high specificity and lot-to-lot reproducibility. Supplied as 100 ug.
AdipoGen Irisin recHEK293
Recombinant protein. Irisin human, aa 32-143 /mouse, aa 29-140 is FLAG -tagged at the N-terminus. Irisin has 100% identity between mouse, rat, monkey and human. Source HEK 293 cells. Lyophilized. Contains PBS. Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin. Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.