Clinical Chemistry Controls
Biotium Serum Amyloid A (SAA/2868R), CF740 conjugate, 0.1mg/mL
This antibody reacts with natural and recombinant human Serum Amyloid A (SAA) and does not cross-react with other human cytokines or growth factors. Human SAA proteins are a group of apo-lipoproteins found predominantly in the high-density lipoprotein (HDL) fraction of plasma. SAA is a major acute-phase protein and precursor to amyloid A protein, which is the major constituent of the fibril deposits of reactive amyloidosis. SAA is secreted in large amounts by the liver during microbial infections or inflammatory diseases.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
ABclonal Technology Serotonin transporter Rabbit pAb
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodiumneurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression.
ABclonal Technology Complement factor B CFB
This gene encodes complement factor B a component of the alternative pathway of complement activation Factor B circulates in the blood as a single chain polypeptide Upon activation of the alternative pathway it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase Bb is involved in the proliferation of preactivated B lymphocytes while Ba inhibits their proliferation This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 This cluster includes several genes involved in regulation of the immune reaction Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration The polyadenylation site of this gene is 421 bp from the 5 end of the gene for complement component 2
CPC Scientific H-Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr-OH (trifluoroacetate salt) 5MG
This tridecapeptide, an alpha-factor pheromone of Saccharomyces cerevisiae, induces conjugation in yeast by binding to Ste2p. Its cognate GPCR activates a G protein signal pathway that highly conserves with mammalian signaling pathways. ONE-LETTER SEQUENCE: WHWLQLKPGQPMYMOLECULAR FORMULA: C82H114N20O17S1MOLECULAR WEIGHT:1684STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [59401-28-4], RESEARCH AREA: HormonalREFERENCES: Lee, BK. et al. J. Biol. Chem. 276, 37950 (2001); Mayrhofer, S. and S. Pöggeler Eukaryot. Cell 4, 661 (2005).
Biotium Catenin, gamma (Cardiomyocyte Marker)(CTNG/2155R), CF647 conjugate, 0.1mg/mL
Gamma catenin, also known as JUP or junction plakoglobin, is a member of the catenin family. The catenins (alpha, beta, gamma, and delta) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion, including adherens junctions. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
AURORA BIOLABS LLC PD-1/PD-L1 Inhibitor Binding Assay Kit,384 rxn
Immune checkpoint blockade is an important cancer immunotherapy strategy that enhances the immune system’s ability to recognize and destroy tumor cells. The PD-1/PD-L1 signaling pathway is a key immune checkpoint that suppresses T-cell activity and allows cancer cells to evade immune surveillance. Blocking the interaction between PD-1 and PD-L1 can restore immune function and improve anti-tumor responses. The PD-1/PD-L1 Inhibitor Binding Assay is a TR-FRET–based assay designed to quantitatively measure the interaction between PD-1 and PD-L1. In this assay, binding of PD-1 to PD-L1 generates a fluorescence resonance energy transfer (FRET) signal that can be detected by measuring fluorescence emission at 665 nm and 620 nm. Compounds or antibodies that inhibit PD-1/PD-L1 binding reduce the TR-FRET signal, enabling evaluation of potential immune checkpoint inhibitors for cancer research and drug discovery applications.
Cusabio Technology LLC apolipoprotein B100
This ELISA kit is designed for the quantitative detection of Rat apolipoprotein B100 (Apo-B100) in serum plasma and tissue homogenates using a competitive assay format The kit demonstrates a detection range of 0 313 g/mL to 20 g/mL with a sensitivity threshold of 0 342 g/mL enabling precise measurement of low-abundance samples The protocol requires 50-100 L of sample per test and delivers results within 1-5 hours through absorbance readings at 450 nm Its optimized competitive binding methodology ensures specific identification of APOB while minimizing cross-reactivity making it suitable for research applications involving lipid metabolism studies cardiovascular disease models and biomarker validation in rodent systems
Meso Scale Discovery R-PLEX Human Cystatin B ASYQP
The R-PLEX Human Cystatin B Assay Kit from Meso Scale Discovery is a multiplex immunoassay for measuring Cystatin B in human serum plasma and other fluids It uses MSD s electrochemiluminescent detection technology offering high sensitivity a broad dynamic range and low sample volume requirements The kit includes a 96-well plate with capture antibodies a detection antibody conjugate calibrator solutions and necessary reagents It detects Cystatin B from 19 pg/mL to 100 000 pg/mL with high specificity
ABclonal Technology Ferritin Heavy Chain Rabbit
This gene encodes the heavy subunit of ferritin the major intracellular iron storage protein in prokaryotes and eukaryotes It is composed of 24 subunits of the heavy and light ferritin chains Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues A major function of ferritin is the storage of iron in a soluble and nontoxic state Defects in ferritin proteins are associated with several neurodegenerative diseases This gene has multiple pseudogenes Several alternatively spliced transcript variants have been observed but their biological validity has not been determined
ONE LAMBDA INC LABScreen Negative Control Serum, 1 Vial, 20 Tests
LABSCREEN NEGATIVE CONTROL SERUM VI=20T
Cayman Chemical FerrItIn PROTAC DeFer-2 5mg
A PROTAC that drives ferritin degradation; induces ferritin degradation in B16/F10 cells at 0.5 µM; increases intracellular levels of free iron and induces pyroptosis in B16/F10 cells at 5 µM; ferritin PROTAC DeFer-2 encapsulated in albumin nanoparticles reduces tumor growth and increases survival in a B16/F10 murine melanoma model at 10 mg/kg
American Research Products Inc Mouse Complement factor I CFI
Mouse Complement factor I (CFI) ELISA kit from CUSABIO Detection Range 0 78 ng/mL-50 ng/mL Sensitivity 0 195 ng/mL Sample serum plasma tissue homogenates cell lysates Method Sandwich
Maine Molecular Quality Controls Inc INTROL CF Panel II Control
INTROL CF Panel II Control is intended for in vitro use as a quality control to monitor analytical performance of the extraction, amplification and detection steps of test systems used in the qualitative measurement of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. This product is intended to be extracted and analyzed routinely with each cystic fibrosis (CF) test run. This product is designed to monitor the detection of 54 CFTR mutations, genetic risk factors associated with cystic fibrosis, including the original 23 mutations recommended for testing by ACMG and ACOG. INTROL CF Panel II Control also monitors variants I506V, I507V, F508C, 5/7/9/11T and I148T. G110 contains: 3 bottles, 2 milliliters each.
Biotium Serum Amyloid A (SAA/2868R), CF647 conjugate, 0.1mg/mL
This antibody reacts with natural and recombinant human Serum Amyloid A (SAA) and does not cross-react with other human cytokines or growth factors. Human SAA proteins are a group of apo-lipoproteins found predominantly in the high-density lipoprotein (HDL) fraction of plasma. SAA is a major acute-phase protein and precursor to amyloid A protein, which is the major constituent of the fibril deposits of reactive amyloidosis. SAA is secreted in large amounts by the liver during microbial infections or inflammatory diseases.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
AdipoGen Digoxin
Chemical. CAS 20830-75-5. Formula C41H64O14. MW 780.94. Synthetic. Cardiac glycoside from the leaves of Digitalis lanata. It is used to treat cardiac arrhythmias. It is often used as a model substrate of P-glycoprotein Pgp 0.01-10µM and an inhibitor of Na/K-ATPase. Inhibits membrane-bound alpha-subunits of the Na/K ATPase pump in myocytes. The primary mechanism of action involves inhibition of the Na/K ATPase, mainly in the myocardium. This inhibition causes an increase in intracellular sodium levels, resulting in a reversal of the action of the sodium-calcium exchanger, which causes an increase in the intracellular calcium concentration. This leads to a decrease in heart rate and increased storage of calcium in the sarcoplasmic reticulum, causing a corresponding increase in the release of calcium during each action potential.