The Meso Scale Discovery SARS-CoV-2 S1 RBD N501Y Kit is a research use only immunoassay that detects antibodies generated in response to the SARS-CoV-2 spike protein receptor binding domain containing the N501Y mutation This mutation is present in several SARS-CoV-2 variants of concern including Alpha Beta and Gamma The assay uses MSD electrochemiluminescence detection technology and provides quantitative measurement of IgG antibodies specific for the SARS-CoV-2 S1 RBD N501Y protein The kit includes reagents for 96 tests and can be run on MSD instrument platforms It allows sensitive high-throughput antibody testing to track immune responses to SARS-CoV-2 variants