Isotopically Labeled Compounds
Medchemexpress LLC Ketoprofen-13C,d3 | 1189508-77-7 | 1 MG
Ketoprofen-13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements for quantitation during drug development.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Desloratadine-d5 | 1020719-34-9 | >99.7% | 1 MG
Desloratadine-d5 is a deuterium-labeled version of Desloratadine, an orally active major metabolite of the nonsedating H1-antihistamine Loratadine. It functions as a selective H1-receptor antagonist with anti-allergic and anti-inflammatory activities.
- Used as a tracer for quantitative analysis
- Acts as a selective H1-receptor antagonist
- Possesses anti-allergic and anti-inflammatory properties
- Can serve as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes for drug development and quantitation
- Deuteration can impact pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Nifedipine-d6 (BAY-a-1040-d6) | 1188266-14-9 | 1 MG
Nifedipine-d6 (BAY-a-1040-d6) is a deuterium labeled nifedipine, which acts as a potent calcium channel blocker. It is intended for research use only. Deuteration, the incorporation of stable heavy isotopes of hydrogen into drug molecules, has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Metronidazole-d3 | 83413-09-6 | MFCD27702816 | 100.0% | 1 MG
Metronidazole-d3 is a deuterium-labeled form of Metronidazole. It can be used for research purposes, including as a tracer or an internal standard for quantitative analysis by techniques like NMR, GC-MS, or LC-MS. This compound typically appears as a light yellow to yellow solid.
- Can be used as a tracer.
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Contains stable heavy isotopes incorporated into drug molecules.
- Deuteration offers potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Sulfamethoxazole-d4 | 1020719-86-1 | 99.3% | 1 ML
Sulfamethoxazole-d4 is a deuterium-labeled sulfonamide antibiotic, also known as Ro 4-2130-d4. It demonstrates widespread antibacterial activity by inhibiting bacterial folate metabolism, specifically by competing with 4-Aminobenzoic acid (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. This product is intended for research use only.
- Deuterium labeled analog
- Sulfonamide antibiotic with widespread antibacterial activity
- Inhibits bacterial folate metabolism
- Suitable for studying urinary tract infections (UTIs), prostatitis, and bronchitis
- Supplied as a 10 mM solution in DMSO
Medchemexpress LLC Fingolimod-d4 hydrochloride | 1346604-90-7 | 99.0% | 347.96 | 100 MG
Fingolimod-d4 hydrochloride is the deuterium-labeled version of Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) acts as a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells, and also functions as a pak1 activator and an immunosuppressant.
- Can be utilized as a tracer.
- Can be used as an internal standard for quantitative analysis through techniques such as NMR, GC-MS, or LC-MS.
- Deuteration has been noted for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Coenzyme Q10-d9 | 2687960-97-8 | 98.2% | 872.40 | 1 MG
Coenzyme Q10-d9 is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Camptothecin-d5 | 1329616-37-6 | 99.6% | 353.38 | 5 MG
Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), an alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. It shows strong antineoplastic activity against colorectal, breast, lung, and ovarian cancers, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering microRNA (miRNA) expression patterns in human cancer cells.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Olmesartan-d4 | 1420880-41-6 | 98.8% | 450.53 | 5 MG
Olmesartan-d4 (RNH-6270-d4) is the deuterium-labeled version of Olmesartan, an angiotensin II receptor (AT1R) antagonist. It is primarily used to treat high blood pressure. This compound can serve as a tracer and an internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS.
- Used as a tracer for quantitation during drug development
- Can be an internal standard for quantitative analysis
- AT1 receptor antagonist
- Deuterium-labeled compound
- Suitable for NMR, GC-MS, or LC-MS applications
Medchemexpress LLC Maribavir-d6 | 176161-24-3 | 99.8% | 382.27 | 1 MG
Maribavir-d6 (1263W94-d6) is a deuterium labeled Maribavir (HY-16305). Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC50 of 3 nM.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Estradiol-13C2 (β-estradiol-13C2) | 82938-05-4 | 1 MG
Estradiol-13C2 is the 13C-labeled version of Estradiol, which is a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. Estradiol also upregulates IL-6 expression via the estrogen receptor β (ERβ) pathway.
- Used as a tracer
- Serves as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS
- It is a 13C-labeled compound, indicating it is a stable isotope
Medchemexpress LLC D-Glucose-13C-5 | 106032-62-6 | 98.0% | 25 MG
D-Glucose-13C-5 is the 13C labeled D-Glucose. D-Glucose, a monosaccharide, is an important carbohydrate in biology. It serves as a carbohydrate sweetener and a critical component of general metabolism, acting as a signaling molecule for cellular metabolic status and stress response. This product is for research use only.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes for quantitation during drug development
Medchemexpress LLC Morpholine-d4 hydrochloride | 1115228-35-7 | 127.61 | 250 MG
Morpholine-d4 hydrochloride is the deuterium labeled Morpholine hydrochloride. It is for research use only and not sold to patients.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Isovaleric acid-d9 | 344298-81-3 | 98.5% | 111.19 | 50 MG
Isovaleric acid-d9 is a deuterium-labeled version of Isovaleric acid, which is a natural fatty acid known to affect neonatal death and potentially Jamaican vomiting sickness in humans. It is intended for research use only.
- Deuterium labeled isovaleric acid.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC (S)-Cystathionine-d4 | 61949-06-2 | 97.1% | 226.29 | 1 MG
(S)-Cystathionine-d4 is the deuterium labeled (S)-Cystathionine. It is for research use only and not sold to patients. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.