PPTN hydrochloride is a potent, high-affinity, competitive, and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. It exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. It also demonstrates anti-inflammatory and anti-immune activity.
- Strong selectivity for the P2Y14 receptor.
- No agonist or antagonist effect at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors.
- Inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells.
- Decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38.
- Significantly decreases the expressions of NLRP3, ASC, and caspase-1 p20 in synovial tissue of rats.
- Significantly decreases the colocalization of NLRP3 and ASC in synovial tissues of rats.