Hs00004075_cn

• Gene Symbol: LOC286059
• Assay Reference Genome Location: Chr.8:23069153 on build GRCh38
• Cytoband: 8p21.3

Target Gene Details

• Entrez Gene ID: 286059
• Gene Name: tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain pseudogene
• Gene Aliases: -
• Location: Chr.8:23068229-23083619 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC286059	NR_038873.1
	AK024295.1

Target Gene Details

• Entrez Gene ID: 8795
• Gene Name: TNF receptor superfamily member 10b
• Gene Aliases: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
• Location: Chr.8:23020133-23069187 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TNFRSF10B	NM_003842.4			NP_003833.4
	NM_147187.2			NP_671716.2
	NR_027140.1
	AL529460.3
	DA738472.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1027718	Chr.8:22805950 - 23258334 on Build GRCh38	Gain	LOC389641 CHMP7 RHOBTB2 TNFRSF10B LOC254896 TNFRSF10D TNFRSF10A TNFRSF10C LOC101929237 LOC107984124 PEBP4 LOC286059
nsv1025672	Chr.8:22868571 - 23130480 on Build GRCh38	Gain	RHOBTB2 TNFRSF10B LOC254896 TNFRSF10C LOC101929237 LOC107984124 PEBP4 LOC286059
nsv1015967	Chr.8:23056273 - 23105040 on Build GRCh38	Loss	TNFRSF10B LOC254896 TNFRSF10C LOC286059
esv2759604	Chr.8:20675533 - 23254096 on Build GRCh38	Loss	BIN3-IT1 DMTN LOC286114 RHOBTB2 TNFRSF10B MIR320A POLR3D LOC107986876 XPO7 BMP1 LOC102467222 LOC101929172 LOC389641 C8orf58 SFTPC CHMP7 SLC39A14 NUDT18 DOK2 CCAR2 PIWIL2 TNFRSF10C LOC101929237 LOC107984124 FAM160B2 NPM2 LGI3 LOC100507071 PHYHIP SORBS3 BIN3 PEBP4 LOC286059 HR PDLIM2 FGF17 EGR3 PPP3CC GFRA2 LOC254896 TNFRSF10D TNFRSF10A REEP4
esv2736750	Chr.8:23028863 - 23201144 on Build GRCh38	Deletion	TNFRSF10B LOC254896 TNFRSF10D TNFRSF10A TNFRSF10C LOC286059
nsv1017570	Chr.8:22969562 - 23544783 on Build GRCh38	Gain	R3HCC1 RHOBTB2 TNFRSF10B LOC286059 SLC25A37 LOC389641 CHMP7 LOXL2 LOC254896 ENTPD4 TNFRSF10D LOC100507156 TNFRSF10A TNFRSF10C LOC107984124

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
cell surface receptor signaling pathway
activation of NF-kappaB-inducing kinase activity
multicellular organism development
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to endoplasmic reticulum stress
regulation of cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to mechanical stimulus
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

receptor activity
tumor necrosis factor-activated receptor activity
protein binding
TRAIL binding