Hs00004075_cn

• Gene Symbol: LOC286059
• Assay Reference Genome Location: Chr.8:23069153 on build GRCh38
• Cytoband: 8p21.3

Target Gene Details

• Entrez Gene ID: 286059
• Gene Name: tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain pseudogene
• Gene Aliases: -
• Location: Chr.8:23068229-23083619 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC286059	NR_038873.1
	AK024295.1

Target Gene Details

• Entrez Gene ID: 8795
• Gene Name: TNF receptor superfamily member 10b
• Gene Aliases: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
• Location: Chr.8:23020133-23069187 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TNFRSF10B	NM_003842.4			NP_003833.4
	NM_147187.2			NP_671716.2
	NR_027140.1
	AL529460.3
	DA738472.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1027718	Chr.8:22805950 - 23258334 on Build GRCh38	Gain	RHOBTB2 LOC101929237 TNFRSF10D LOC286059 PEBP4 TNFRSF10A TNFRSF10B LOC389641 TNFRSF10C LOC107984124 LOC254896 CHMP7
nsv1025672	Chr.8:22868571 - 23130480 on Build GRCh38	Gain	RHOBTB2 LOC101929237 LOC286059 PEBP4 TNFRSF10B TNFRSF10C LOC107984124 LOC254896
nsv1015967	Chr.8:23056273 - 23105040 on Build GRCh38	Loss	LOC286059 TNFRSF10B TNFRSF10C LOC254896
esv2759604	Chr.8:20675533 - 23254096 on Build GRCh38	Loss	SFTPC TNFRSF10D SLC39A14 LOC286114 TNFRSF10B BIN3-IT1 LOC107984124 DMTN C8orf58 PIWIL2 BIN3 LOC101929172 PDLIM2 LOC101929237 TNFRSF10A LOC389641 TNFRSF10C LGI3 LOC100507071 PHYHIP RHOBTB2 MIR320A PPP3CC NUDT18 PEBP4 POLR3D CCAR2 FGF17 HR SORBS3 LOC254896 CHMP7 EGR3 LOC107986876 LOC102467222 XPO7 BMP1 GFRA2 LOC286059 FAM160B2 NPM2 REEP4 DOK2
nsv1017570	Chr.8:22969562 - 23544783 on Build GRCh38	Gain	RHOBTB2 LOXL2 TNFRSF10D SLC25A37 TNFRSF10B LOC100507156 LOC107984124 ENTPD4 LOC254896 CHMP7 LOC286059 TNFRSF10A LOC389641 R3HCC1 TNFRSF10C
esv2736750	Chr.8:23028863 - 23201144 on Build GRCh38	Deletion	TNFRSF10D LOC286059 TNFRSF10A TNFRSF10B TNFRSF10C LOC254896

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
cell surface receptor signaling pathway
activation of NF-kappaB-inducing kinase activity
multicellular organism development
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to endoplasmic reticulum stress
regulation of cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to mechanical stimulus
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

receptor activity
tumor necrosis factor-activated receptor activity
protein binding
TRAIL binding