Hs00028743_cn

• Gene Symbol: LOC286059
• Assay Reference Genome Location: Chr.8:23068934 on build GRCh38
• Cytoband: 8p21.3

Target Gene Details

• Entrez Gene ID: 286059
• Gene Name: tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain pseudogene
• Gene Aliases: -
• Location: Chr.8:23068229-23083619 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC286059	NR_038873.1
	AK024295.1

Target Gene Details

• Entrez Gene ID: 8795
• Gene Name: TNF receptor superfamily member 10b
• Gene Aliases: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
• Location: Chr.8:23020133-23069187 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TNFRSF10B	NM_003842.4	1	254	NP_003833.4
	NM_147187.2	1	254	NP_671716.2
	NR_027140.1	1	254
	AB451272.1
	AB451399.1
	AF012535.1	1	100	AAB67103.1
	AF012628.1			AAB67109.1
	AF016266.1	1	78	AAB81180.1
	AF016268.1	1	70	AAC01565.1
	AF016849.1	1	105	AAC51778.1
	AF018657.1			AAB70577.1
	AF018658.1			AAB70578.1
	AF020501.1			AAB71412.1
	AF022386.1			AAB71949.1
	AF153687.1	1	79	AAF75587.1
	AF192548.1	1	61	AAF07175.1
	AK291216.1	1	81
	AK298602.1	1	98
	AL529460.3	1	254
	AY358277.1	1	100	AAQ88644.1
	BC001281.1	1	108	AAH01281.1
	BX538104.1	1	94	CAD98017.1
	CR541898.1			CAG46696.1
	DA738472.1	1	254
	DA889488.1	1	98
	FJ200482.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1027718	Chr.8:22805950 - 23258334 on Build GRCh38	Gain	RHOBTB2 LOC389641 TNFRSF10A LOC101929237 CHMP7 TNFRSF10C PEBP4 LOC286059 TNFRSF10D LOC107984124 TNFRSF10B LOC254896
nsv1025672	Chr.8:22868571 - 23130480 on Build GRCh38	Gain	RHOBTB2 LOC101929237 TNFRSF10C PEBP4 LOC286059 LOC107984124 TNFRSF10B LOC254896
nsv1015967	Chr.8:23056273 - 23105040 on Build GRCh38	Loss	TNFRSF10C LOC286059 TNFRSF10B LOC254896
esv2759604	Chr.8:20675533 - 23254096 on Build GRCh38	Loss	LGI3 LOC101929237 NPM2 POLR3D TNFRSF10C FAM160B2 PEBP4 FGF17 LOC107986876 TNFRSF10D BIN3 CCAR2 LOC286114 TNFRSF10A PIWIL2 LOC102467222 REEP4 NUDT18 LOC107984124 SLC39A14 SORBS3 XPO7 MIR320A PPP3CC RHOBTB2 BIN3-IT1 PHYHIP LOC389641 HR CHMP7 LOC101929172 DOK2 SFTPC LOC254896 BMP1 C8orf58 GFRA2 DMTN LOC286059 LOC100507071 PDLIM2 EGR3 TNFRSF10B
nsv1017570	Chr.8:22969562 - 23544783 on Build GRCh38	Gain	RHOBTB2 LOC389641 CHMP7 LOC100507156 TNFRSF10C LOXL2 TNFRSF10D LOC254896 TNFRSF10A R3HCC1 LOC286059 ENTPD4 LOC107984124 TNFRSF10B SLC25A37
esv2736750	Chr.8:23028863 - 23201144 on Build GRCh38	Deletion	TNFRSF10A TNFRSF10C LOC286059 TNFRSF10D TNFRSF10B LOC254896

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
cell surface receptor signaling pathway
activation of NF-kappaB-inducing kinase activity
multicellular organism development
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to endoplasmic reticulum stress
regulation of cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to mechanical stimulus
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

receptor activity
tumor necrosis factor-activated receptor activity
protein binding
TRAIL binding