Hs00092447_cn

• Gene Symbol: IRF4
• Assay Reference Genome Location: Chr.6:391759 on build GRCh38
• Cytoband: 6p25.3

Target Gene Details

• Entrez Gene ID: 3662
• Gene Name: interferon regulatory factor 4
• Gene Aliases: LSIRF, MUM1, NF-EM5, SHEP8
• Location: Chr.6:391739-411443 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
IRF4	NM_001195286.1			NP_001182215.1
	NM_002460.3			NP_002451.2
	NR_046000.2
	XM_006715090.2			XP_006715153.1
	AK310149.1
	D78261.1			BAA11335.1
	U52682.1			AAC50779.1
	U63738.1			AAB37258.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv736n27	Chr.6:253861 - 394293 on Build GRCh38	Loss	IRF4 DUSP22
dgv5872n100	Chr.6:231934 - 397937 on Build GRCh38	Gain	IRF4 DUSP22
nsv823390	Chr.6:295899 - 452604 on Build GRCh38	Gain	IRF4 DUSP22
nsv820552	Chr.6:254458 - 396285 on Build GRCh38	Duplication	IRF4 DUSP22
nsv509115	Chr.6:360763 - 416001 on Build GRCh38	Insertion	IRF4
dgv990n67	Chr.6:254941 - 396689 on Build GRCh38	Gain	IRF4 DUSP22
nsv1028946	Chr.6:334825 - 404771 on Build GRCh38	Gain	IRF4 DUSP22
nsv821644	Chr.6:182761 - 411478 on Build GRCh38	Gain	LOC285766 IRF4 DUSP22
nsv830568	Chr.6:232604 - 411249 on Build GRCh38	Gain+Loss	IRF4 DUSP22
esv3607852	Chr.6:381951 - 500339 on Build GRCh38	Loss	EXOC2 IRF4
dgv5869n100	Chr.6:149649 - 395798 on Build GRCh38	Gain	LOC285766 IRF4 DUSP22
nsv600779	Chr.6:383546 - 439985 on Build GRCh38	Loss	IRF4
esv3607835	Chr.6:180946 - 734275 on Build GRCh38	Loss	LOC285766 EXOC2 IRF4 DUSP22 HUS1B
dgv5884n100	Chr.6:257341 - 447036 on Build GRCh38	Gain	IRF4 DUSP22
nsv428134	Chr.6:60001 - 653718 on Build GRCh38	Gain	LOC285766 EXOC2 IRF4 LINC00266-3 DUSP22

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

winged helix/forkhead transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
peptidyl-lysine methylation
negative regulation of toll-like receptor signaling pathway
T cell activation
defense response to protozoan
myeloid dendritic cell differentiation
positive regulation of DNA binding
histone H3 acetylation
histone H4 acetylation
positive regulation of interleukin-10 biosynthetic process
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-13 biosynthetic process
positive regulation of interleukin-4 biosynthetic process
regulation of T-helper cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
T-helper 17 cell lineage commitment

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein-lysine N-methyltransferase activity
sequence-specific DNA binding