Hs00123357_cn

• Gene Symbol: TNFRSF10B
• Assay Reference Genome Location: Chr.8:23021623 on build GRCh38
• Cytoband: 8p21.3

Target Gene Details

• Entrez Gene ID: 8795
• Gene Name: TNF receptor superfamily member 10b
• Gene Aliases: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
• Location: Chr.8:23020133-23069187 on Build GRCh38
• Assay Gene Location: Within Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TNFRSF10B	NM_003842.4	9	2664	NP_003833.4
	NM_147187.2	10	2577	NP_671716.2
	NR_027140.1	9	2471
	XM_017013944.1	9	2452	XP_016869433.1
	AF016266.1	9	2488	AAB81180.1
	BX537617.1	4	1769	CAD97801.1
	BX538104.1	9	2493	CAD98017.1
	BX538179.1	4	1769	CAD98053.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1027718	Chr.8:22805950 - 23258334 on Build GRCh38	Gain	LOC107984124 LOC286059 CHMP7 TNFRSF10D TNFRSF10B TNFRSF10C RHOBTB2 LOC389641 TNFRSF10A LOC101929237 PEBP4 LOC254896
nsv524231	Chr.8:23003729 - 23028617 on Build GRCh38	Loss	TNFRSF10B RHOBTB2
nsv1025672	Chr.8:22868571 - 23130480 on Build GRCh38	Gain	LOC107984124 LOC286059 TNFRSF10B TNFRSF10C RHOBTB2 LOC101929237 PEBP4 LOC254896
esv2759604	Chr.8:20675533 - 23254096 on Build GRCh38	Loss	DMTN SORBS3 NPM2 TNFRSF10B PIWIL2 PPP3CC SLC39A14 LOC101929172 BMP1 LOC102467222 POLR3D PDLIM2 CCAR2 MIR320A XPO7 TNFRSF10A LOC101929237 PEBP4 LOC286059 DOK2 PHYHIP SFTPC HR GFRA2 LOC286114 LOC100507071 LOC107986876 LOC254896 LOC107984124 CHMP7 NUDT18 LGI3 BIN3-IT1 BIN3 TNFRSF10D C8orf58 TNFRSF10C FAM160B2 RHOBTB2 REEP4 LOC389641 FGF17 EGR3
nsv1017570	Chr.8:22969562 - 23544783 on Build GRCh38	Gain	LOC286059 LOC100507156 TNFRSF10B R3HCC1 SLC25A37 LOC254896 LOC107984124 LOXL2 CHMP7 TNFRSF10D TNFRSF10C RHOBTB2 LOC389641 TNFRSF10A ENTPD4

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
cell surface receptor signaling pathway
activation of NF-kappaB-inducing kinase activity
multicellular organism development
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to endoplasmic reticulum stress
regulation of cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to mechanical stimulus
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

receptor activity
tumor necrosis factor-activated receptor activity
protein binding
TRAIL binding