Hs00123472_cn

• Gene Symbol: LOC286059
• Assay Reference Genome Location: Chr.8:23068828 on build GRCh38
• Cytoband: 8p21.3

Target Gene Details

• Entrez Gene ID: 286059
• Gene Name: tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain pseudogene
• Gene Aliases: -
• Location: Chr.8:23068229-23083619 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC286059	NR_038873.1
	AK024295.1

Target Gene Details

• Entrez Gene ID: 8795
• Gene Name: TNF receptor superfamily member 10b
• Gene Aliases: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
• Location: Chr.8:23020133-23069187 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TNFRSF10B	NM_003842.4	1	360	NP_003833.4
	NM_147187.2	1	360	NP_671716.2
	NR_027140.1	1	360
	AB451272.1	1	67
	AB451399.1	1	67
	AF012535.1	1	206	AAB67103.1
	AF012628.1	1	67	AAB67109.1
	AF016266.1	1	184	AAB81180.1
	AF016268.1	1	176	AAC01565.1
	AF016849.1	1	211	AAC51778.1
	AF018657.1	1	67	AAB70577.1
	AF018658.1	1	67	AAB70578.1
	AF020501.1	1	67	AAB71412.1
	AF022386.1	1	67	AAB71949.1
	AF153687.1	1	185	AAF75587.1
	AF192548.1	1	167	AAF07175.1
	AK291216.1	1	187
	AK298602.1	1	204
	AL529460.3	1	360
	AY358277.1	1	206	AAQ88644.1
	BC001281.1	1	214	AAH01281.1
	BX538104.1	1	200	CAD98017.1
	CR541898.1	1	67	CAG46696.1
	DA738472.1	1	360
	DA889488.1	1	204
	FJ200482.1	1	67

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1027718	Chr.8:22805950 - 23258334 on Build GRCh38	Gain	LOC286059 LOC107984124 TNFRSF10D TNFRSF10C LOC389641 PEBP4 TNFRSF10A TNFRSF10B CHMP7 LOC254896 RHOBTB2 LOC101929237
nsv1025672	Chr.8:22868571 - 23130480 on Build GRCh38	Gain	LOC286059 LOC107984124 TNFRSF10C PEBP4 TNFRSF10B LOC254896 RHOBTB2 LOC101929237
nsv1015967	Chr.8:23056273 - 23105040 on Build GRCh38	Loss	LOC286059 TNFRSF10C TNFRSF10B LOC254896
esv2759604	Chr.8:20675533 - 23254096 on Build GRCh38	Loss	LOC107986876 DMTN LOC107984124 LOC389641 BIN3-IT1 MIR320A PHYHIP LOC286059 HR TNFRSF10C CCAR2 TNFRSF10B REEP4 SFTPC FGF17 RHOBTB2 PIWIL2 PDLIM2 SORBS3 EGR3 LOC101929237 LOC102467222 LOC286114 LGI3 TNFRSF10D PEBP4 LOC100507071 LOC101929172 TNFRSF10A XPO7 PPP3CC DOK2 NPM2 C8orf58 FAM160B2 BIN3 BMP1 NUDT18 POLR3D SLC39A14 CHMP7 GFRA2 LOC254896
nsv1017570	Chr.8:22969562 - 23544783 on Build GRCh38	Gain	LOC107984124 TNFRSF10D LOC389641 TNFRSF10A LOC100507156 LOXL2 LOC286059 TNFRSF10C ENTPD4 TNFRSF10B CHMP7 LOC254896 R3HCC1 RHOBTB2 SLC25A37
esv2736750	Chr.8:23028863 - 23201144 on Build GRCh38	Deletion	LOC286059 TNFRSF10D TNFRSF10C TNFRSF10A TNFRSF10B LOC254896

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
cell surface receptor signaling pathway
activation of NF-kappaB-inducing kinase activity
multicellular organism development
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to endoplasmic reticulum stress
regulation of cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to mechanical stimulus
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

receptor activity
tumor necrosis factor-activated receptor activity
protein binding
TRAIL binding