Hs00123472_cn

• Gene Symbol: LOC286059
• Assay Reference Genome Location: Chr.8:23068828 on build GRCh38
• Cytoband: 8p21.3

Target Gene Details

• Entrez Gene ID: 286059
• Gene Name: tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain pseudogene
• Gene Aliases: -
• Location: Chr.8:23068229-23083619 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC286059	NR_038873.1
	AK024295.1

Target Gene Details

• Entrez Gene ID: 8795
• Gene Name: TNF receptor superfamily member 10b
• Gene Aliases: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
• Location: Chr.8:23020133-23069187 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TNFRSF10B	NM_003842.4	1	360	NP_003833.4
	NM_147187.2	1	360	NP_671716.2
	NR_027140.1	1	360
	AB451272.1	1	67
	AB451399.1	1	67
	AF012535.1	1	206	AAB67103.1
	AF012628.1	1	67	AAB67109.1
	AF016266.1	1	184	AAB81180.1
	AF016268.1	1	176	AAC01565.1
	AF016849.1	1	211	AAC51778.1
	AF018657.1	1	67	AAB70577.1
	AF018658.1	1	67	AAB70578.1
	AF020501.1	1	67	AAB71412.1
	AF022386.1	1	67	AAB71949.1
	AF153687.1	1	185	AAF75587.1
	AF192548.1	1	167	AAF07175.1
	AK291216.1	1	187
	AK298602.1	1	204
	AL529460.3	1	360
	AY358277.1	1	206	AAQ88644.1
	BC001281.1	1	214	AAH01281.1
	BX538104.1	1	200	CAD98017.1
	CR541898.1	1	67	CAG46696.1
	DA738472.1	1	360
	DA889488.1	1	204
	FJ200482.1	1	67

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1027718	Chr.8:22805950 - 23258334 on Build GRCh38	Gain	TNFRSF10B LOC107984124 TNFRSF10C LOC254896 PEBP4 TNFRSF10D LOC286059 LOC101929237 CHMP7 LOC389641 RHOBTB2 TNFRSF10A
nsv1025672	Chr.8:22868571 - 23130480 on Build GRCh38	Gain	TNFRSF10B LOC107984124 TNFRSF10C LOC254896 PEBP4 LOC286059 LOC101929237 RHOBTB2
nsv1015967	Chr.8:23056273 - 23105040 on Build GRCh38	Loss	TNFRSF10B TNFRSF10C LOC254896 LOC286059
esv2759604	Chr.8:20675533 - 23254096 on Build GRCh38	Loss	LOC107984124 BIN3 FGF17 PDLIM2 PIWIL2 C8orf58 DMTN LOC100507071 MIR320A POLR3D NUDT18 LOC101929172 TNFRSF10B TNFRSF10C PPP3CC PEBP4 SLC39A14 REEP4 LOC286059 LOC101929237 BMP1 GFRA2 CCAR2 LOC254896 DOK2 LOC102467222 BIN3-IT1 XPO7 SORBS3 LOC107986876 LGI3 FAM160B2 HR LOC286114 SFTPC TNFRSF10D NPM2 CHMP7 LOC389641 RHOBTB2 PHYHIP TNFRSF10A EGR3
esv2736750	Chr.8:23028863 - 23201144 on Build GRCh38	Deletion	TNFRSF10B TNFRSF10C LOC254896 TNFRSF10D LOC286059 TNFRSF10A
nsv1017570	Chr.8:22969562 - 23544783 on Build GRCh38	Gain	LOC107984124 ENTPD4 TNFRSF10B LOXL2 TNFRSF10C LOC254896 LOC100507156 R3HCC1 SLC25A37 TNFRSF10D LOC286059 CHMP7 LOC389641 RHOBTB2 TNFRSF10A

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
cell surface receptor signaling pathway
activation of NF-kappaB-inducing kinase activity
multicellular organism development
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to endoplasmic reticulum stress
regulation of cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to mechanical stimulus
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

receptor activity
tumor necrosis factor-activated receptor activity
protein binding
TRAIL binding