Hs00360138_cn

• Gene Symbol: RACK1
• Assay Reference Genome Location: Chr.5:181238251 on build GRCh38
• Cytoband: 5q35.3

Target Gene Details

• Entrez Gene ID: 10399
• Gene Name: receptor for activated C kinase 1
• Gene Aliases: GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21
• Location: Chr.5:181236928-181243906 on Build GRCh38
• Assay Gene Location: Overlaps Intron 5 - Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RACK1	NM_006098.4			NP_006089.1
	AK095666.1
	AK222488.1			BAD96208.1
	AK301029.1
	AK301468.1
	AY336089.1			AAR24619.1
	BC000214.1			AAH00214.1
	BC000366.2			AAH00366.1
	BC010119.2			AAH10119.1
	BC014256.1			AAH14256.1
	BC014788.1			AAH14788.1
	BC017287.2			AAH17287.1
	BC019093.2			AAH19093.1
	BC019362.1			AAH19362.1
	BC021993.1			AAH21993.1
	BC032006.1			AAH32006.1
	CR456978.1			CAG33259.1
	CR541909.1			CAG46707.1
	GU727632.1
	M24194.1			AAA59626.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1028730	Chr.5:181236035 - 181292789 on Build GRCh38	Gain	TRIM52 TRIM52-AS1 RACK1 SNORD95 SNORD96A CTC-338M12.4
nsv428133	Chr.5:180805451 - 181359487 on Build GRCh38	Gain	LINC00847 TRIM52-AS1 OR4F3 SNORD95 SNORD96A MIR8089 ZFP62 MGAT1 TRIM7 OR2V2 LOC100132062 TRIM52 HEIH RACK1 BTNL3 OR2V1 LOC102577426 MIR4638 BTNL8 TRIM41 BTNL9 CTC-338M12.4
nsv600731	Chr.5:181195615 - 181263936 on Build GRCh38	Loss	TRIM52 TRIM52-AS1 RACK1 SNORD95 SNORD96A MIR4638 TRIM7 TRIM41 CTC-338M12.4
nsv830567	Chr.5:181103365 - 181255322 on Build GRCh38	Loss	TRIM52 RACK1 SNORD95 SNORD96A OR2V1 LOC102577426 MIR4638 TRIM7 TRIM41 OR2V2 CTC-338M12.4
nsv517697	Chr.5:181180883 - 181263936 on Build GRCh38	Loss	TRIM52 TRIM52-AS1 RACK1 SNORD95 SNORD96A LOC102577426 MIR4638 TRIM7 TRIM41 CTC-338M12.4

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

osteoblast differentiation
positive regulation of protein phosphorylation
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell cycle
gastrulation
negative regulation of gene expression
regulation of tumor necrosis factor-mediated signaling pathway
viral process
negative regulation of translation
negative regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of cell migration
positive regulation of cAMP catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein homooligomerization
regulation of protein localization
negative regulation of peptidyl-serine phosphorylation
positive regulation of Golgi to plasma membrane protein transport
positive regulation of apoptotic process
positive regulation of GTPase activity
rhythmic process
negative regulation of phagocytosis
regulation of cell division
positive regulation of cyclic-nucleotide phosphodiesterase activity
regulation of cell cycle
negative regulation of protein kinase B signaling
positive regulation of mitochondrial depolarization
negative regulation of protein tyrosine kinase activity
cellular response to glucose stimulus
cellular response to growth factor stimulus
cell-cell adhesion
negative regulation of endoplasmic reticulum unfolded protein response
negative regulation of hydrogen peroxide-induced neuron death
regulation of establishment of cell polarity
positive regulation of ceramide biosynthetic process
positive regulation of gastrulation
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

protein kinase C binding
receptor binding
protein binding
ion channel inhibitor activity
cysteine-type endopeptidase activator activity involved in apoptotic process
enzyme binding
protein phosphatase binding
protein tyrosine kinase inhibitor activity
receptor tyrosine kinase binding
protein complex scaffold
signaling adaptor activity
SH2 domain binding
protein homodimerization activity
poly(A) RNA binding
cadherin binding involved in cell-cell adhesion