Hs00502549_cn

• Gene Symbol: FZD8
• Assay Reference Genome Location: Chr.10:35638524 on build GRCh38
• Cytoband: 10p11.21

Target Gene Details

• Entrez Gene ID: 8325
• Gene Name: frizzled class receptor 8
• Gene Aliases: FZ-8, hFZ8
• Location: Chr.10:35638249-35641434 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FZD8	NM_031866.2	1	2911	NP_114072.1
	AB043703.1	1	2911	BAB41064.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv144n67	Chr.10:35600010 - 35681917 on Build GRCh38	Gain	GJD4 FZD8 MIR4683
nsv521143	Chr.10:35624277 - 35647825 on Build GRCh38	Loss	FZD8 MIR4683
dgv1034n54	Chr.10:35600599 - 35673959 on Build GRCh38	Loss	GJD4 FZD8 MIR4683
nsv825341	Chr.10:35638193 - 35643553 on Build GRCh38	Gain	FZD8 MIR4683
nsv825340	Chr.10:35628179 - 35651436 on Build GRCh38	Gain	FZD8 MIR4683
dgv1035n54	Chr.10:35631696 - 35644550 on Build GRCh38	Loss	FZD8 MIR4683
nsv825337	Chr.10:35583021 - 35685326 on Build GRCh38	Gain	GJD4 FZD8 MIR4683
nsv550413	Chr.10:35638239 - 35644550 on Build GRCh38	Loss	FZD8 MIR4683

More Information

Additional Information:

For this assay, SNP(s) [rs74893196] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
angiogenesis
G-protein coupled receptor signaling pathway
neuron differentiation
T cell differentiation in thymus
non-canonical Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of transcription from RNA polymerase II promoter
canonical Wnt signaling pathway

Function(s)

G-protein coupled receptor activity
receptor binding
protein binding
Wnt-protein binding
PDZ domain binding
ubiquitin protein ligase binding
Wnt-activated receptor activity