Hs00622657_cn

• Gene Symbol: EIF2AK2
• Assay Reference Genome Location: Chr.2:37106625 on build GRCh38
• Cytoband: 2p22.2

Target Gene Details

• Entrez Gene ID: 5610
• Gene Name: eukaryotic translation initiation factor 2 alpha kinase 2
• Gene Aliases: EIF2AK1, PKR, PPP1R83, PRKR
• Location: Chr.2:37099210-37157065 on Build GRCh38
• Assay Gene Location: Within Exon 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EIF2AK2	NM_001135651.2	17	2627	NP_001129123.1
	NM_001135652.2	14	2197	NP_001129124.1
	NM_002759.3	17	2861	NP_002750.1
	XM_011532987.2	17	2561	XP_011531289.1
	XM_017004503.1	16	2428	XP_016859992.1
	AI360504.1	1	41
	BM473760.1
	F03305.1	1	70
	M35663.1	16	2490	AAA36409.1
	M85294.1	15	2334	AAA18253.1

More Information

• Set Membership: Intragenic, Exonic, non-DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
positive regulation of cytokine production
transcription, DNA-templated
translation
protein phosphorylation
negative regulation of cell proliferation
response to mechanical stimulus
response to virus
response to toxic substance
regulation of translational initiation by eIF2 alpha phosphorylation
negative regulation of translation
peptidyl-tyrosine phosphorylation
evasion or tolerance by virus of host immune response
endoplasmic reticulum unfolded protein response
response to lipopolysaccharide
positive regulation of chemokine production
positive regulation of stress-activated MAPK cascade
response to vitamin E
negative regulation of osteoblast proliferation
regulation of protein phosphatase type 2A activity
cellular response to amino acid starvation
response to interferon-alpha
positive regulation of apoptotic process
negative regulation of apoptotic process
response to exogenous dsRNA
negative regulation of viral genome replication
innate immune response
protein autophosphorylation
positive regulation of NF-kappaB transcription factor activity
defense response to virus
regulation of NLRP3 inflammasome complex assembly
positive regulation of NIK/NF-kappaB signaling
regulation of hematopoietic progenitor cell differentiation
regulation of hematopoietic stem cell proliferation
regulation of hematopoietic stem cell differentiation

Function(s)

double-stranded RNA binding
protein kinase activity
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
protein phosphatase type 2A regulator activity
poly(A) RNA binding