Hs00864367_cn

• Gene Symbol: USP18
• Assay Reference Genome Location: Chr.22:18150092 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 11274
• Gene Name: ubiquitin specific peptidase 18
• Gene Aliases: ISG43, UBP43
• Location: Chr.22:18149959-18177397 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
USP18	NM_017414.3	1	102	NP_059110.2
	XM_006724074.2	1	134	XP_006724137.1
	AI222587.1	2	316
	BI752849.1
	BU584005.1	1	139

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1055756	Chr.22:18062621 - 18794021 on Build GRCh38	Gain	GGT3P USP18 LOC642643 RIMBP3 TUBA8 TMEM191B PI4KAP1 LOC100996401 LOC729461 PEX26 FAM230A LOC100996415
nsv516997	Chr.22:18143870 - 19039100 on Build GRCh38	Gain+Loss	LOC642643 PI4KAP1 LOC100996401 LOC102725072 DGCR5 DGCR9 FAM230A LOC100996415 PRODH GGT3P USP18 RIMBP3 TMEM191B LOC100996432 LOC729461 DGCR2 DGCR10 DGCR6
nsv1058565	Chr.22:18060494 - 18159378 on Build GRCh38	Gain	USP18 TUBA8 PEX26
esv3893430	Chr.22:18059545 - 18169093 on Build GRCh38	Gain	USP18 TUBA8 PEX26
esv2751935	Chr.22:18149609 - 19042823 on Build GRCh38	Loss	LOC642643 PI4KAP1 LOC100996401 LOC102725072 DGCR5 DGCR9 FAM230A LOC100996415 PRODH GGT3P USP18 RIMBP3 TMEM191B LOC100996432 LOC729461 DGCR2 DGCR10 DGCR6
nsv428385	Chr.22:17491941 - 18886703 on Build GRCh38	Gain+Loss	BCL2L13 SLC25A18 MIR648 LOC100996401 LOC102725072 FLJ41941 PEX26 FAM230A USP18 LOC100996432 LINC00528 LOC642643 MIR3198-1 PI4KAP1 LOC101929372 BID ATP6V1E1 LOC100996415 GGT3P CECR2 RIMBP3 TUBA8 TMEM191B LOC729461 MICAL3
esv2758824	Chr.22:18069029 - 19074200 on Build GRCh38	Gain+Loss	LOC642643 PI4KAP1 LOC100996401 LOC102725072 DGCR5 DGCR9 PEX26 FAM230A LOC100996415 PRODH GGT3P USP18 DGCR11 RIMBP3 TUBA8 TMEM191B LOC100996432 LOC729461 DGCR2 DGCR10 DGCR6
nsv471594	Chr.22:18076012 - 18882129 on Build GRCh38	Gain+Loss	LOC642643 PI4KAP1 LOC100996401 LOC102725072 PEX26 FAM230A LOC100996415 GGT3P USP18 RIMBP3 TUBA8 TMEM191B LOC100996432 LOC729461
nsv469560	Chr.22:18076011 - 18213970 on Build GRCh38	Gain	USP18 TUBA8 PEX26 LOC100996415

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

cysteine protease

Gene Ontology Categories:

Process(es)

ubiquitin-dependent protein catabolic process
protein deubiquitination
regulation of type I interferon-mediated signaling pathway

Function(s)

thiol-dependent ubiquitin-specific protease activity
protein binding
ISG15-specific protease activity