Hs00883147_cn

• Gene Symbol: THRB
• Assay Reference Genome Location: Chr.3:24120003 on build GRCh38
• Cytoband: 3p24.2

Target Gene Details

• Entrez Gene ID: 7068
• Gene Name: thyroid hormone receptor beta
• Gene Aliases: C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
• Location: Chr.3:24117153-24495281 on Build GRCh38
• Assay Gene Location: Within Exon 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
THRB	NM_000461.4	10	4552	NP_000452.2
	NM_001128176.2	11	4663	NP_001121648.1
	NM_001128177.1	11	4689	NP_001121649.1
	NM_001252634.1	12	4787	NP_001239563.1
	XM_005265421.4	11	4760	XP_005265478.1
	XM_005265423.4	10	4595	XP_005265480.1
	XM_005265424.3	10	4530	XP_005265481.1
	XM_006713317.3	11	4903	XP_006713380.1
	XM_006713318.3	11	4855	XP_006713381.1
	XM_011534046.2	11	6803	XP_011532348.1
	XM_011534047.2	12	5040	XP_011532349.1
	XM_011534048.2	11	4619	XP_011532350.1
	XM_011534049.2	10	4475	XP_011532351.1
	XM_011534050.2	11	4848	XP_011532352.1
	XM_011534051.2	10	4438	XP_011532353.1
	XM_011534052.2	11	4575	XP_011532354.1
	XM_011534053.2	10	4696	XP_011532355.1
	XM_017007108.1	12	4973	XP_016862597.1
	XM_017007109.1	13	5131	XP_016862598.1
	XM_017007110.1	12	4938	XP_016862599.1
	XM_017007111.1	11	4584	XP_016862600.1
	XM_017007112.1	10	4554	XP_016862601.1
	XM_017007113.1	9	4693	XP_016862602.1
	XM_017007114.1	9	4658	XP_016862603.1
	XM_017007115.1	9	4532	XP_016862604.1
	AK095776.1	1	1981
	AK098084.1	1	852
	GQ869477.1	1	2881
	GQ869478.1	2	2758

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv834639	Chr.3:23995622 - 24192434 on Build GRCh38	Gain	LOC101927854 THRB LINC00691

More Information

Additional Information:

For this assay, SNP(s) [rs79270057] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor, DNA-binding transcription factor, zinc finger transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
sensory perception of sound
negative regulation of female receptivity
regulation of heart contraction
female courtship behavior
organ morphogenesis
intracellular receptor signaling pathway
steroid hormone mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
Type I pneumocyte differentiation

Function(s)

DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription corepressor activity
thyroid hormone receptor activity
protein binding
zinc ion binding
enzyme binding
chromatin DNA binding
sequence-specific DNA binding
thyroid hormone binding