Hs01130065_cn

• Gene Symbol: LOC105377621
• Assay Reference Genome Location: Chr.4:102501335 on build GRCh38
• Cytoband: 4q24

Target Gene Details

• Entrez Gene ID: 105377621
• Gene Name: uncharacterized LOC105377621
• Gene Aliases: -
• Location: Chr.4:102418602-102502486 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC105377621	NR_136202.1

Target Gene Details

• Entrez Gene ID: 4790
• Gene Name: nuclear factor kappa B subunit 1
• Gene Aliases: CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
• Location: Chr.4:102501329-102617302 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NFKB1	NM_001165412.1			NP_001158884.1
	NM_003998.3			NP_003989.2
	BC051765.1			AAH51765.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv4442	Chr.4:102498046 - 102529664 on Build GRCh38	Insertion	LOC105377621 NFKB1
esv27559	Chr.4:102501056 - 102501786 on Build GRCh38	Loss	LOC105377621 NFKB1
nsv830020	Chr.4:102466186 - 102660127 on Build GRCh38	Loss	LOC105377621 NFKB1 MANBA

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

Rel homology transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
stimulatory C-type lectin receptor signaling pathway
transcription from RNA polymerase II promoter
apoptotic process
inflammatory response
response to oxidative stress
I-kappaB kinase/NF-kappaB signaling
positive regulation of macrophage derived foam cell differentiation
positive regulation of lipid storage
negative regulation of calcidiol 1-monooxygenase activity
negative regulation of vitamin D biosynthetic process
membrane protein intracellular domain proteolysis
negative regulation of cellular protein metabolic process
negative regulation of cholesterol transport
positive regulation of type I interferon production
response to muscle stretch
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
negative regulation of apoptotic process
negative regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to copper ion
negative regulation of inflammatory response
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to nicotine
cellular response to carbohydrate stimulus
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to dsRNA
cellular response to peptide hormone stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of hyaluronan biosynthetic process
cellular response to diterpene
cellular response to glucoside
cellular response to brain-derived neurotrophic factor stimulus
positive regulation of miRNA metabolic process

Function(s)

regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
heat shock protein binding
identical protein binding
protein homodimerization activity
actinin binding
transcription regulatory region DNA binding
protein heterodimerization activity