Hs01333916_cn

• Gene Symbol: ADORA2A
• Assay Reference Genome Location: Chr.22:24430928 on build GRCh38
• Cytoband: 22q11.23

Target Gene Details

• Entrez Gene ID: 135
• Gene Name: adenosine A2a receptor
• Gene Aliases: A2aR, ADORA2, RDC8
• Location: Chr.22:24423597-24442360 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A	NM_000675.5			NP_000666.2
	NM_001278499.1			NP_001265428.1
	NM_001278500.1			NP_001265429.1
	NR_103543.1
	NR_103544.1
	AK123058.1
	AK301420.1
	BC013780.1			AAH13780.1
	DA781734.1
	DA942067.1
	DA983859.1
	EU036693.1
	EU036694.1
	HY102778.1

Target Gene Details

• Entrez Gene ID: 646023
• Gene Name: ADORA2A antisense RNA 1
• Gene Aliases: C22orf45
• Location: Chr.22:24429206-24495074 on Build GRCh38
• Assay Gene Location: Overlaps Intron 10 - Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A-AS1	NR_028484.2
	AK091970.1

Target Gene Details

• Entrez Gene ID: 101730217
• Gene Name: SPECC1L-ADORA2A readthrough (NMD candidate)
• Gene Aliases: -
• Location: Chr.22:24270817-24442360 on Build GRCh38
• Assay Gene Location: Within Intron 18

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SPECC1L-ADORA2A	NR_103546.1
	AB209022.1			BAD92259.1
	GR939218.1
	GR939229.1
	GR939241.1
	GR939262.1
	GR939274.1
	GR939286.1
	GR939298.1
	GR939310.1
	GR939322.1
	GR939334.1
	GR939358.1
	GR939370.1
	GR939382.1
	GR939394.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2724068	Chr.22:24288741 - 24669870 on Build GRCh38	Deletion	GGT1 SPECC1L SNRPD3 POM121L10P BCRP3 ADORA2A LRRC75B SPECC1L-ADORA2A ADORA2A-AS1 GUCD1 UPB1
dgv8039n54	Chr.22:23323169 - 24601506 on Build GRCh38	Gain	GSTT2B LOC107985559 IGLL1 LOC107985555 GSTT2 LRRC75B ADORA2A-AS1 LOC101929374 UPB1 DRICH1 MIF-AS1 CABIN1 SMARCB1 ADORA2A CHCHD10 DDT C22orf15 MMP11 SLC2A11 DERL3 MIF GGT1 DDTL CES5AP1 SNRPD3 POM121L9P GUCD1 SUSD2 GUSBP11 RGL4 LOC100652871 LOC388882 VPREB3 GSTTP1 ZDHHC8P1 SPECC1L PCAT14 SPECC1L-ADORA2A GGT5 ZNF70
nsv1057819	Chr.22:24290518 - 24624081 on Build GRCh38	Gain	GGT1 SPECC1L SNRPD3 ADORA2A LRRC75B SPECC1L-ADORA2A ADORA2A-AS1 GUCD1 UPB1
nsv526567	Chr.22:23348138 - 24600663 on Build GRCh38	Gain	GSTT2B LOC107985559 IGLL1 LOC107985555 GSTT2 LRRC75B ADORA2A-AS1 LOC101929374 UPB1 DRICH1 MIF-AS1 CABIN1 SMARCB1 ADORA2A CHCHD10 DDT C22orf15 MMP11 SLC2A11 DERL3 MIF GGT1 DDTL CES5AP1 SNRPD3 POM121L9P GUCD1 SUSD2 GUSBP11 RGL4 LOC100652871 LOC388882 VPREB3 GSTTP1 ZDHHC8P1 SPECC1L PCAT14 SPECC1L-ADORA2A GGT5 ZNF70
esv2724041	Chr.22:23315914 - 24669376 on Build GRCh38	Deletion	GSTT2B LOC107985559 IGLL1 LOC107985555 GSTT2 LRRC75B ADORA2A-AS1 LOC101929374 UPB1 DRICH1 MIF-AS1 CABIN1 SMARCB1 POM121L10P ADORA2A CHCHD10 DDT C22orf15 BCR MMP11 SLC2A11 DERL3 MIF GGT1 DDTL CES5AP1 SNRPD3 POM121L9P GUCD1 SUSD2 GUSBP11 RGL4 LOC100652871 LOC388882 VPREB3 GSTTP1 ZDHHC8P1 SPECC1L PCAT14 BCRP3 SPECC1L-ADORA2A GGT5 ZNF70
nsv1055830	Chr.22:24005071 - 24643213 on Build GRCh38	Gain	GGT1 SNRPD3 LRRC75B ADORA2A-AS1 POM121L9P GUCD1 SUSD2 UPB1 GSTTP1 CABIN1 SPECC1L BCRP3 ADORA2A SPECC1L-ADORA2A GGT5
esv3893463	Chr.22:24009046 - 24601506 on Build GRCh38	Gain	GGT1 SNRPD3 LRRC75B ADORA2A-AS1 POM121L9P GUCD1 SUSD2 UPB1 CABIN1 SPECC1L ADORA2A SPECC1L-ADORA2A GGT5
dgv4528n100	Chr.22:23322244 - 24682765 on Build GRCh38	Gain	GSTT2B LOC107985559 IGLL1 LOC107985555 GSTT2 LRRC75B ADORA2A-AS1 LOC101929374 UPB1 DRICH1 MIF-AS1 CABIN1 SMARCB1 POM121L10P ADORA2A CHCHD10 DDT C22orf15 MMP11 SLC2A11 DERL3 MIF GGT1 DDTL CES5AP1 SNRPD3 POM121L9P GUCD1 SUSD2 GUSBP11 RGL4 LOC100652871 LOC388882 VPREB3 GSTTP1 ZDHHC8P1 SPECC1L PCAT14 BCRP3 SPECC1L-ADORA2A GGT5 ZNF70
nsv588744	Chr.22:24285587 - 24617379 on Build GRCh38	Gain	GGT1 SPECC1L SNRPD3 ADORA2A LRRC75B SPECC1L-ADORA2A ADORA2A-AS1 GUCD1 UPB1
nsv9884	Chr.22:24415625 - 24662249 on Build GRCh38	Gain+Loss	GGT1 SPECC1L SNRPD3 POM121L10P BCRP3 ADORA2A LRRC75B SPECC1L-ADORA2A ADORA2A-AS1 GUCD1 UPB1
esv3575443	Chr.22:23348201 - 24670505 on Build GRCh38	Gain	GSTT2B LOC107985559 IGLL1 LOC107985555 GSTT2 LRRC75B ADORA2A-AS1 LOC101929374 UPB1 DRICH1 MIF-AS1 CABIN1 SMARCB1 POM121L10P ADORA2A CHCHD10 DDT C22orf15 MMP11 SLC2A11 DERL3 MIF GGT1 DDTL CES5AP1 SNRPD3 POM121L9P GUCD1 SUSD2 GUSBP11 RGL4 LOC100652871 LOC388882 VPREB3 GSTTP1 ZDHHC8P1 SPECC1L PCAT14 BCRP3 SPECC1L-ADORA2A GGT5 ZNF70
nsv834160	Chr.22:24329972 - 24507687 on Build GRCh38	Gain	SPECC1L ADORA2A SPECC1L-ADORA2A ADORA2A-AS1 UPB1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

adenosine receptor signaling pathway
cAMP biosynthetic process
phagocytosis
apoptotic process
inflammatory response
cellular defense response
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell-cell signaling
central nervous system development
blood coagulation
sensory perception
blood circulation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
cellular protein metabolic process

Function(s)

G-protein coupled adenosine receptor activity
protein binding
enzyme binding
identical protein binding