Hs01446649_cn

• Gene Symbol: ARHGEF11
• Assay Reference Genome Location: Chr.1:156935266 on build GRCh38
• Cytoband: 1q23.1

Target Gene Details

• Entrez Gene ID: 9826
• Gene Name: Rho guanine nucleotide exchange factor 11
• Gene Aliases: GTRAP48, PDZ-RHOGEF
• Location: Chr.1:156934840-157046903 on Build GRCh38
• Assay Gene Location: Within Exon 47

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ARHGEF11	NM_014784.3	40	6343	NP_055599.1
	NM_198236.2	41	6463	NP_937879.1
	XM_005245629.4	41	6867	XP_005245686.1
	XM_005245633.4	31	4726	XP_005245690.1
	XM_006711659.2	43	6915	XP_006711722.1
	XM_006711660.3	43	6912	XP_006711723.1
	XM_006711661.2	42	6885	XP_006711724.1
	XM_006711662.2	42	6882	XP_006711725.1
	XM_006711663.3	41	5902	XP_006711726.1
	XM_006711665.3	42	6792	XP_006711728.1
	XM_011510185.2	42	6900	XP_011508487.1
	XM_011510186.2	42	6795	XP_011508488.1
	XM_011510187.2	42	5626	XP_011508489.1
	XM_011510189.2	20	4931	XP_011508491.1
	XM_017002920.1	42	6882	XP_016858409.1
	XM_017002921.1	40	6834	XP_016858410.1
	XM_017002922.1	41	6762	XP_016858411.1
	XM_017002923.1	40	6747	XP_016858412.1
	XM_017002924.1	40	6747	XP_016858413.1
	AL832790.1	10	4374
	BC057394.1	41	6487	AAH57394.1

Target Gene Details

• Entrez Gene ID: 149499
• Gene Name: leucine rich repeat containing 71
• Gene Aliases: C1orf92
• Location: Chr.1:156920608-156941208 on Build GRCh38
• Assay Gene Location: Within Intron 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LRRC71	XM_017000459.1			XP_016855948.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3890682	Chr.1:156899922 - 156951428 on Build GRCh38	Loss	MIR765 ARHGEF11 PEAR1 LRRC71
nsv831659	Chr.1:156771159 - 156980204 on Build GRCh38	Loss	MIR765 PRCC NTRK1 INSRR ARHGEF11 SH2D2A PEAR1 LRRC71

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

guanyl-nucleotide exchange factor, non-motor microtubule binding protein

Gene Ontology Categories:

Process(es)

cytokinesis
regulation of cell growth
movement of cell or subcellular component
striated muscle contraction
G-protein coupled receptor signaling pathway
Rho protein signal transduction
establishment of cell polarity
actin cytoskeleton organization
regulation of Rho protein signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of transcription, DNA-templated
regulation of small GTPase mediated signal transduction

Function(s)

G-protein coupled receptor binding
guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
GTPase activator activity
protein binding