Hs01570337_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67175126 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001185057.2	4	891	NP_001171986.1
	NM_001276307.1	6	925	NP_001263236.1
	NM_001276309.1	4	785	NP_001263238.1
	NM_001276311.1	4	777	NP_001263240.1
	NM_001276312.1	6	1276	NP_001263241.1
	NM_001276319.1	6	1276	NP_001263248.1
	NM_003946.6	4	901	NP_003937.1
	XM_005256217.2	4	1528	XP_005256274.1
	XM_005256219.3	4	1414	XP_005256276.1
	XM_011523424.2	5	1373	XP_011521726.1
	XM_017023843.1	4	1538	XP_016879332.1
	AF043244.1	4	818	AAC34993.1
	AF064599.1	4	742	AAC18593.1
	AF064600.1	4	776	AAC18594.1
	AK294145.1	6	1241
	BC012798.2	4	787	AAH12798.1
	BP215200.1
	BQ685512.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	FAM65A LOC100505942 DPEP2 SLC9A5 DUS2 PSMB10 CENPT CTRL TSNAXIP1 C16orf86 HSF4 ATP6V0D1 PARD6A NRN1L LOC107984813 PLEKHG4 TMEM208 KCTD19 RANBP10 EXOC3L1 FBXL8 CTCF DDX28 ZDHHC1 HSD11B2 LOC105369155 LRRC29 ACD NUTF2 LCAT CARMIL2 TRADD LOC100131303 EDC4 MIR328 PSKH1 ELMO3 NOL3 AGRP FHOD1 LRRC36 GFOD2 E2F4 SLC12A4 ENKD1 DPEP3 TPPP3 THAP11 KIAA0895L
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	ELMO3 NOL3 LOC105369155 LRRC29 TMEM208 FHOD1 C16orf70 E2F4 EXOC3L1 TRADD HSF4 FBXL8 B3GNT9 MIR328 KIAA0895L
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	ELMO3 NOL3 PLEKHG4 SLC9A5 LOC105369155 LRRC29 TMEM208 FHOD1 C16orf70 E2F4 EXOC3L1 TRADD HSF4 FBXL8 B3GNT9 MIR328 KIAA0895L
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	ELMO3 E2F4 EXOC3L1 NOL3 HSF4 LOC105369155 LRRC29 FBXL8 MIR328 KIAA0895L
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	FAM65A LOC100505942 DPEP2 SLC9A5 DUS2 PSMB10 CENPT CTRL TSNAXIP1 C16orf86 HSF4 ATP6V0D1 PARD6A NRN1L LOC107984813 PLEKHG4 TMEM208 KCTD19 RANBP10 EXOC3L1 FBXL8 CTCF DDX28 ZDHHC1 HSD11B2 LOC105369155 LRRC29 ACD C16orf70 NUTF2 LCAT CARMIL2 TRADD LOC100131303 EDC4 B3GNT9 MIR328 PSKH1 ELMO3 NOL3 AGRP FHOD1 LRRC36 GFOD2 E2F4 SLC12A4 ENKD1 DPEP3 TPPP3 THAP11 KIAA0895L
nsv471092	Chr.16:67174030 - 67518392 on Build GRCh38	Gain	ELMO3 LOC100505942 NOL3 PLEKHG4 ZDHHC1 HSD11B2 AGRP SLC9A5 LOC105369155 LRRC29 TMEM208 KCTD19 FHOD1 LRRC36 E2F4 EXOC3L1 ATP6V0D1 MIR328 TPPP3 KIAA0895L

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding