Hs01721527_cn

• Gene Symbol: POLA2
• Assay Reference Genome Location: Chr.11:65281147 on build GRCh38
• Cytoband: 11q13.1

Target Gene Details

• Entrez Gene ID: 23649
• Gene Name: DNA polymerase alpha 2, accessory subunit
• Gene Aliases: -
• Location: Chr.11:65261852-65306269 on Build GRCh38
• Assay Gene Location: Overlaps Exon 8 - Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
POLA2	NM_002689.3			NP_002680.2
	XM_011544877.2			XP_011543179.1
	XM_011544878.2			XP_011543180.1
	XM_011544879.1			XP_011543181.1
	XM_011544881.2			XP_011543183.1
	XM_017017452.1			XP_016872941.1
	AK025315.1
	AK094569.1
	AK297842.1
	AK307831.1
	BC001347.2			AAH01347.1
	BC002990.1			AAH02990.1
	CR456737.1			CAG33018.1
	L24559.1			AAA16459.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422285	Chr.11:65245823 - 65487069 on Build GRCh38	Deletion	MIR612 POLA2 NEAT1 DPF2 SLC25A45 TIGD3 CDC42EP2 FRMD8 LOC101927789
nsv832190	Chr.11:65210673 - 65360142 on Build GRCh38	Loss	POLA2 DPF2 TIGD3 CDC42EP2 CAPN1 SLC22A20
nsv526181	Chr.11:64870569 - 65489858 on Build GRCh38	Gain	MIR194-2HG MIR612 VPS51 SLC25A45 CAPN1 SNX15 MAJIN PPP2R5B ARL2-SNX15 TMEM262 NAALADL1 POLA2 NEAT1 MRPL49 CDC42EP2 SLC22A20 CDCA5 ZFPL1 TM7SF2 FAU MIR6879 MIR194-2 SAC3D1 MIR6749 ZNHIT2 SYVN1 FRMD8 EHD1 LOC101927789 GPHA2 MIR192 MIR6751 ATG2A DPF2 TIGD3 SPDYC MIR6750 BATF2 ARL2

More Information

Additional Information:

For this assay, SNP(s) [rs113829757] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-directed DNA polymerase

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
G1/S transition of mitotic cell cycle
telomere maintenance via recombination
DNA replication
DNA replication initiation
DNA strand elongation involved in DNA replication
DNA biosynthetic process

Function(s)

molecular_function
DNA binding
DNA-directed DNA polymerase activity
protein heterodimerization activity