Hs01790461_cn

• Gene Symbol: HGS
• Assay Reference Genome Location: Chr.17:81693950 on build GRCh38
• Cytoband: 17q25.3

Target Gene Details

• Entrez Gene ID: 9146
• Gene Name: hepatocyte growth factor-regulated tyrosine kinase substrate
• Gene Aliases: HRS
• Location: Chr.17:81683932-81702121 on Build GRCh38
• Assay Gene Location: Overlaps Intron 11 - Intron 12

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HGS	NM_004712.4			NP_004703.1
	XM_011525463.2			XP_011523765.1
	XM_017025297.1			XP_016880786.1
	XM_017025298.1			XP_016880787.1
	AF260566.1			AAF82361.1
	AK303800.1
	BC003565.1			AAH03565.1
	BT009754.1			AAP88756.1
	D84064.1			BAA23366.1
	KU178466.1
	KU178467.1
	U43895.1			AAC51929.1

Target Gene Details

• Entrez Gene ID: 102465471
• Gene Name: microRNA 6786
• Gene Aliases: hsa-mir-6786
• Location: Chr.17:81693757-81693869 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MIR6786	NR_106844.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv828128	Chr.17:80659041 - 81736487 on Build GRCh38	Loss	MIR1250 HGS LOC100130370 MIR3186 CHMP6 RPTOR MIR3065 BAIAP2 LOC100129503 LOC105371921 LINC00482 MIR657 FSCN2 BAIAP2-AS1 NPLOC4 OXLD1 BAHCC1 MIR6786 SLC25A10 LOC107985021 CEP131 LOC101928855 AATK FAAP100 TEPSIN ACTG1 LOC400627 TSPAN10 MIR338 MRPL12 SLC38A10 ARL16 PDE6G C17orf89 AATK-AS1 LOC105371925 TMEM105 MIR4740 LOC107985022 CCDC137
nsv428351	Chr.17:81152631 - 83064073 on Build GRCh38	Gain	HGS LOC105376790 MYADML2 LOC101929511 ANAPC11 P4HB MIR4525 ASPSCR1 SNORD134 LOC105376791 LOC101929552 BAHCC1 MIR6786 RAC3 MIR6787 HEXDC CEP131 AATK B3GNTL1 FOXK2 TBCD TSPAN10 GPS1 SIRT7 ZNF750 SLC38A10 ARL16 PDE6G SECTM1 MAFG-AS1 C17orf89 C17orf62 NARF RAB40B RFNG DCXR CCDC57 PCYT2 CSNK1D TMEM105 PPP1R27 NOTUM LRRC45 LOC100130370 MIR3186 ARHGDIA GCGR MAFG CD7 SLC16A3 LINC00482 STRA13 FSCN2 NPLOC4 OXLD1 FN3KRP TEX19 DUS1L SLC25A10 UTS2R OGFOD3 MCRIP1 FAAP100 TEPSIN ACTG1 LOC105371944 WDR45B MRPL12 FN3K PYCR1 NPB AATK-AS1 LOC105371925 ALYREF MIR4740 FASN CCDC137
nsv470620	Chr.17:81516973 - 82064485 on Build GRCh38	Loss	HGS MYADML2 ANAPC11 ARHGDIA GCGR P4HB MAFG ASPSCR1 STRA13 FSCN2 NPLOC4 OXLD1 MIR6786 RAC3 DUS1L SLC25A10 MCRIP1 FAAP100 TSPAN10 GPS1 MRPL12 SIRT7 ARL16 PDE6G MAFG-AS1 PYCR1 NPB RFNG DCXR PCYT2 PPP1R27 ALYREF CCDC137 NOTUM LRRC45
nsv952390	Chr.17:81637175 - 81860124 on Build GRCh38	Deletion	HGS MCRIP1 TSPAN10 GCGR P4HB MRPL12 ARL16 PDE6G OXLD1 MIR6786 SLC25A10 PPP1R27 CCDC137

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein targeting to lysosome
autophagy
signal transduction
negative regulation of cell proliferation
membrane invagination
positive regulation of gene expression
endosomal transport
multivesicular body assembly
negative regulation of epidermal growth factor receptor signaling pathway
regulation of protein catabolic process
regulation of MAP kinase activity
negative regulation of JAK-STAT cascade
protein localization to membrane
positive regulation of exosomal secretion

Function(s)

protein binding
protein domain specific binding
metal ion binding