Hs01899819_cn

• Gene Symbol: KDM2B
• Assay Reference Genome Location: Chr.12:121424230 on build GRCh38
• Cytoband: 12q24.31

Target Gene Details

• Entrez Gene ID: 84678
• Gene Name: lysine demethylase 2B
• Gene Aliases: CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2
• Location: Chr.12:121402289-121582268 on Build GRCh38
• Assay Gene Location: Within Intron 26

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
KDM2B	XM_011538867.2			XP_011537169.1

Target Gene Details

• Entrez Gene ID: 80196
• Gene Name: ring finger protein 34
• Gene Aliases: CARP-1, CARP1, RFI, RIF, RIFF, hRFI
• Location: Chr.12:121400083-121424353 on Build GRCh38
• Assay Gene Location: Within Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RNF34	NM_001256858.1	5	1327	NP_001243787.1
	NM_025126.3	6	1903	NP_079402.2
	NM_194271.2	7	1934	NP_919247.1
	AF306709.1	6	1945	AAK51328.1
	AK024957.1	1	1856
	AK025439.1	6	1868	BAB15132.1
	AK096994.1	3	1484
	BC007826.2	6	1828	AAH07826.1

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, non-DGV Variation

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
spermatogenesis
midbrain-hindbrain boundary morphogenesis
fourth ventricle development
lateral ventricle development
third ventricle development
initiation of neural tube closure
positive regulation of cell growth
forebrain development
midbrain development
hindbrain development
histone H2A monoubiquitination
negative regulation of neuron apoptotic process
embryonic camera-type eye morphogenesis
oxidation-reduction process
histone H3-K36 demethylation
positive regulation of stem cell population maintenance
negative regulation of neural precursor cell proliferation
protein polyubiquitination
apoptotic process
protein ubiquitination
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular response to cold
protein K48-linked ubiquitination
negative regulation of signal transduction by p53 class mediator
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of oxygen metabolic process
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Function(s)

RNA polymerase II core promoter sequence-specific DNA binding
DNA binding
protein binding
zinc ion binding
rRNA binding
histone demethylase activity
histone demethylase activity (H3-K36 specific)
p53 binding
ubiquitin-protein transferase activity
ligase activity
ubiquitin protein ligase binding
ubiquitin protein ligase activity
phosphatidylinositol phosphate binding