Hs01990329_cn

• Gene Symbol: POLR3K
• Assay Reference Genome Location: Chr.16:53596 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 51728
• Gene Name: RNA polymerase III subunit K
• Gene Aliases: C11, C11-RNP3, My010, RPC10, RPC11, RPC12.5
• Location: Chr.16:46979-53632 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
POLR3K	NM_016310.4	1	37	NP_057394.3
	AF051316.1			AAF18268.1
	AF060223.1			AAG43123.1
	BC011932.2			AAH11932.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522688	Chr.16:47354 - 55444 on Build GRCh38	Loss	SNRNP25 POLR3K
esv2422427	Chr.16:10001 - 2723164 on Build GRCh38	Duplication	C1QTNF8 FAM173A GNG13 FBXL16 TPSAB1 WDR90 CCDC78 AMDHD2 SNORD60 MIR6511B1 RPL3L MRPS34 TBL3 SNORA78 MIR4717 LOC105371184 SYNGR3 ERVK13-1 MIR3177 PKD1 RHBDL1 MIR6859-4 TSR3 CLCN7 LMF1-AS1 IFT140 CRAMP1 TPSG1 SNHG9 TPSB2 SNRNP25 TMEM8A TMEM204 MIR6767 WDR24 CAPN15 PTX4 TELO2 LUC7L MIR940 SNORA64 CACNA1H E4F1 PIGQ MIR4516 DECR2 MCRIP2 CASKIN1 HS3ST6 PDPK1 ECI1 LOC652276 PRSS27 PGP SSTR5-AS1 NPRL3 TRAF7 CCNF WASIR2 HN1L RAB40C MIR3180-5 NUBP2 ARHGDIG HBQ1 MIR5587 RPUSD1 ATP6V0C PDIA2 FLJ42627 PRR25 RHBDF1 SLC9A3R2 METTL26 MIR6768 LMF1 RNPS1 HBZ CEMP1 KCTD5 LINC00235 SSTR5 LOC107987233 TSC2 MPG LOC106660606 AXIN1 MSLN MIR662 RPL23AP5 RNF151 GNPTG LOC107984876 RAB11FIP3 SOX8 MIR3178 MIR3176 MAPK8IP3 PRSS29P METRN DDX11L10 UBE2I MSRB1 HAGH NOXO1 HBA1 WFIKKN1 ABCA17P RGS11 DNASE1L2 LOC105371038 NTN3 SNORA10 HAGHL LOC729652 STUB1 TPSD1 MEIOB MIR1225 ZNF598 TBC1D24 IGFALS CCDC154 LOC101929280 FAHD1 NPW MLST8 POLR3K NARFL FAM234A LOC105371046 SPSB3 BAIAP3 C16orf59 BRICD5 MRPL28 NME3 RPS2 LINC00254 ABCA3 NTHL1 JMJD8 RHOT2 CHTF18 LOC105371047 NME4 EME2 LOC100134368 MIR3677 RAB26 LOC100287175 HBA2 LOC105371049 UNKL PRR35 HBM C16orf91 NHLRC4 NDUFB10 GFER LOC105371045 SNHG19
nsv1044732	Chr.16:35815 - 60707 on Build GRCh38	Loss	SNRNP25 RHBDF1 POLR3K
dgv2690n100	Chr.16:10765 - 207261 on Build GRCh38	Gain	MIR6859-4 HBZ NPRL3 WASIR2 LUC7L MPG DDX11L10 POLR3K HBA1 HBQ1 HBA2 SNRNP25 RHBDF1 HBM
esv2760065	Chr.16:31052 - 143601 on Build GRCh38	Gain	HBZ NPRL3 SNRNP25 RHBDF1 MPG POLR3K

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-directed RNA polymerase, RNA metabolism protein, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase III promoter
termination of RNA polymerase III transcription
positive regulation of type I interferon production
innate immune response
defense response to virus

Function(s)

RNA polymerase III activity
nucleic acid binding
DNA-directed RNA polymerase activity
zinc ion binding