Hs02018635_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67175303 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001185057.2	4	1068	NP_001171986.1
	NM_001276307.1	6	1102	NP_001263236.1
	NM_001276309.1	4	962	NP_001263238.1
	NM_001276311.1	4	954	NP_001263240.1
	NM_001276312.1	6	1453	NP_001263241.1
	NM_001276319.1	6	1453	NP_001263248.1
	NM_003946.6	4	1078	NP_003937.1
	XM_005256217.2	4	1705	XP_005256274.1
	XM_005256219.3	4	1591	XP_005256276.1
	XM_011523424.2	5	1550	XP_011521726.1
	XM_017023843.1	4	1715	XP_016879332.1
	AF064599.1	4	919	AAC18593.1
	AK294145.1	6	1418
	BC012798.2	4	964	AAH12798.1
	BP215200.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	LOC105369155 LOC100505942 LRRC29 PARD6A CTRL TSNAXIP1 FHOD1 DPEP3 KCTD19 EDC4 FAM65A DPEP2 PLEKHG4 CTCF DDX28 PSKH1 LRRC36 ENKD1 PSMB10 THAP11 ELMO3 DUS2 ACD KIAA0895L RANBP10 E2F4 EXOC3L1 NUTF2 GFOD2 TMEM208 TRADD SLC9A5 NOL3 MIR328 SLC12A4 TPPP3 AGRP CENPT NRN1L C16orf86 FBXL8 HSD11B2 ATP6V0D1 LOC100131303 LCAT CARMIL2 HSF4 ZDHHC1 LOC107984813
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	LOC105369155 LRRC29 KIAA0895L B3GNT9 FBXL8 E2F4 EXOC3L1 TMEM208 HSF4 TRADD C16orf70 FHOD1 SLC9A5 NOL3 ELMO3 PLEKHG4 MIR328
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	LOC105369155 LRRC29 KIAA0895L B3GNT9 FBXL8 E2F4 EXOC3L1 TMEM208 HSF4 TRADD C16orf70 FHOD1 NOL3 ELMO3 MIR328
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	LOC105369155 LRRC29 KIAA0895L FBXL8 NOL3 ELMO3 MIR328 E2F4 EXOC3L1 HSF4
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	LOC105369155 LRRC29 KIAA0895L E2F4 EXOC3L1 TMEM208 FHOD1 SLC9A5 KCTD19 NOL3 ELMO3 PLEKHG4 MIR328
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	LOC105369155 LOC100505942 LRRC29 PARD6A B3GNT9 CTRL TSNAXIP1 FHOD1 DPEP3 KCTD19 EDC4 FAM65A DPEP2 PLEKHG4 CTCF DDX28 PSKH1 LRRC36 ENKD1 PSMB10 THAP11 ELMO3 DUS2 ACD KIAA0895L RANBP10 E2F4 EXOC3L1 NUTF2 GFOD2 TMEM208 TRADD SLC9A5 NOL3 MIR328 SLC12A4 TPPP3 AGRP CENPT NRN1L C16orf86 FBXL8 HSD11B2 ATP6V0D1 LOC100131303 LCAT CARMIL2 HSF4 C16orf70 ZDHHC1 LOC107984813

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding