Hs02018635_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67175303 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001185057.2	4	1068	NP_001171986.1
	NM_001276307.1	6	1102	NP_001263236.1
	NM_001276309.1	4	962	NP_001263238.1
	NM_001276311.1	4	954	NP_001263240.1
	NM_001276312.1	6	1453	NP_001263241.1
	NM_001276319.1	6	1453	NP_001263248.1
	NM_003946.6	4	1078	NP_003937.1
	XM_005256217.2	4	1705	XP_005256274.1
	XM_005256219.3	4	1591	XP_005256276.1
	XM_011523424.2	5	1550	XP_011521726.1
	XM_017023843.1	4	1715	XP_016879332.1
	AF064599.1	4	919	AAC18593.1
	AK294145.1	6	1418
	BC012798.2	4	964	AAH12798.1
	BP215200.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	TRADD RANBP10 DDX28 CENPT FHOD1 E2F4 MIR328 EXOC3L1 LOC105369155 SLC9A5 HSF4 TMEM208 DPEP2 LRRC36 DPEP3 FBXL8 ENKD1 NUTF2 SLC12A4 ZDHHC1 ACD C16orf86 PLEKHG4 THAP11 TSNAXIP1 DUS2 CTCF FAM65A LOC107984813 GFOD2 HSD11B2 KCTD19 AGRP PSMB10 PSKH1 PARD6A CTRL EDC4 NRN1L ELMO3 NOL3 CARMIL2 LOC100131303 LRRC29 ATP6V0D1 LOC100505942 KIAA0895L TPPP3 LCAT
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	ELMO3 TRADD HSF4 NOL3 TMEM208 LRRC29 FBXL8 FHOD1 E2F4 C16orf70 B3GNT9 MIR328 KIAA0895L EXOC3L1 LOC105369155
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	ELMO3 TRADD HSF4 NOL3 TMEM208 LRRC29 FBXL8 FHOD1 E2F4 C16orf70 B3GNT9 MIR328 KIAA0895L EXOC3L1 LOC105369155 PLEKHG4 SLC9A5
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	ELMO3 HSF4 E2F4 NOL3 MIR328 KIAA0895L EXOC3L1 LRRC29 LOC105369155 FBXL8
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	TRADD RANBP10 DDX28 CENPT FHOD1 E2F4 B3GNT9 MIR328 EXOC3L1 LOC105369155 SLC9A5 HSF4 TMEM208 DPEP2 LRRC36 DPEP3 FBXL8 ENKD1 NUTF2 SLC12A4 ZDHHC1 ACD C16orf86 PLEKHG4 THAP11 TSNAXIP1 DUS2 CTCF FAM65A LOC107984813 GFOD2 HSD11B2 KCTD19 AGRP PSMB10 PSKH1 PARD6A CTRL EDC4 NRN1L ELMO3 NOL3 CARMIL2 LOC100131303 LRRC29 ATP6V0D1 LOC100505942 C16orf70 KIAA0895L TPPP3 LCAT
nsv471092	Chr.16:67174030 - 67518392 on Build GRCh38	Gain	ELMO3 NOL3 TMEM208 LRRC29 HSD11B2 ATP6V0D1 LRRC36 KCTD19 LOC100505942 AGRP FHOD1 E2F4 ZDHHC1 MIR328 KIAA0895L EXOC3L1 LOC105369155 PLEKHG4 TPPP3 SLC9A5

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding