Hs02106690_cn

• Gene Symbol: APC2
• Assay Reference Genome Location: Chr.19:1453001 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10297
• Gene Name: APC2, WNT signaling pathway regulator
• Gene Aliases: APCL
• Location: Chr.19:1446268-1473244 on Build GRCh38
• Assay Gene Location: Overlaps Intron 3 - Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APC2	NM_005883.2			NP_005874.1
	XM_005259475.2			XP_005259532.1
	XM_006722607.2			XP_006722670.1
	XM_006722608.3			XP_006722671.2
	XM_006722609.3			XP_006722672.1
	XM_006722610.3			XP_006722673.2
	AB012162.1	1	1713	BAA34611.1
	AF110334.1			AAD28183.1
	AF128222.1	1	204	AAF01784.1
	AJ012652.1	1	204	CAB61207.1
	AL078616.1
	BC032573.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	UQCR11 CSNK1G2 ABHD17A SCAMP4 MIR1909 C19orf25 ONECUT3 NDUFS7 MBD3 TCF3 MUM1 REEP6 APC2 CSNK1G2-AS1 PLK5 REXO1 MEX3D BTBD2 KLF16 DAZAP1 ADAT3 ADAMTSL5 PCSK4 ATP8B3 LOC100288123 RPS15 GAMT
nsv578279	Chr.19:1413575 - 1530061 on Build GRCh38	Gain	ADAMTSL5 PCSK4 RPS15 C19orf25 REEP6 APC2 PLK5 DAZAP1
nsv833705	Chr.19:1380125 - 1544934 on Build GRCh38	Loss	NDUFS7 ADAMTSL5 PCSK4 RPS15 C19orf25 GAMT REEP6 APC2 PLK5 DAZAP1
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	ATP5D LOC102725180 C19orf25 C19orf24 NDUFS7 TMEM259 ARID3A MUM1 CIRBP ARHGAP45 REEP6 APC2 PLK5 CBARP SBNO2 CIRBP-AS1 POLR2E STK11 LOC105372235 GPX4 DAZAP1 ABCA7 GRIN3B ADAMTSL5 MIDN PCSK4 CNN2 RPS15 EFNA2 RNU6-2 GAMT WDR18
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	UQCR11 CSNK1G2 ABHD17A SCAMP4 MIR1909 C19orf25 ONECUT3 MKNK2 NDUFS7 MBD3 TCF3 MUM1 REEP6 APC2 CSNK1G2-AS1 PLK5 REXO1 MEX3D BTBD2 KLF16 DAZAP1 ADAT3 ADAMTSL5 PCSK4 ATP8B3 LOC100288123 RPS15 GAMT
nsv817811	Chr.19:1444420 - 1475392 on Build GRCh38	Loss	C19orf25 APC2

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
cell proliferation
Wnt signaling pathway
cell migration
negative regulation of catenin import into nucleus
regulation of cell differentiation
positive regulation of protein catabolic process
negative regulation of canonical Wnt signaling pathway

Function(s)

protein binding
beta-catenin binding
microtubule binding
gamma-catenin binding