Hs02136499_cn

• Gene Symbol: HGS
• Assay Reference Genome Location: Chr.17:81693743 on build GRCh38
• Cytoband: 17q25.3

Target Gene Details

• Entrez Gene ID: 9146
• Gene Name: hepatocyte growth factor-regulated tyrosine kinase substrate
• Gene Aliases: HRS
• Location: Chr.17:81683932-81702121 on Build GRCh38
• Assay Gene Location: Overlaps Exon 11 - Intron 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HGS	NM_004712.4			NP_004703.1
	XM_011525463.2			XP_011523765.1
	XM_017025297.1			XP_016880786.1
	XM_017025298.1			XP_016880787.1
	AF260566.1			AAF82361.1
	AK303800.1
	BC003565.1			AAH03565.1
	BT009754.1			AAP88756.1
	D84064.1			BAA23366.1
	KU178466.1
	KU178467.1
	U43895.1			AAC51929.1

Target Gene Details

• Entrez Gene ID: 102465471
• Gene Name: microRNA 6786
• Gene Aliases: hsa-mir-6786
• Location: Chr.17:81693757-81693869 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MIR6786	NR_106844.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv828128	Chr.17:80659041 - 81736487 on Build GRCh38	Loss	LOC101928855 NPLOC4 AATK TMEM105 MIR4740 RPTOR C17orf89 ARL16 MRPL12 MIR657 FAAP100 AATK-AS1 MIR3065 LOC100130370 BAIAP2 TEPSIN OXLD1 BAIAP2-AS1 LOC100129503 LOC107985021 MIR338 LOC400627 MIR3186 LOC105371921 FSCN2 CHMP6 LOC105371925 PDE6G MIR6786 ACTG1 LOC107985022 BAHCC1 MIR1250 CCDC137 TSPAN10 SLC38A10 HGS CEP131 LINC00482 SLC25A10
nsv428351	Chr.17:81152631 - 83064073 on Build GRCh38	Gain	NPLOC4 SNORD134 CSNK1D FOXK2 TBCD C17orf62 ARHGDIA TEX19 SIRT7 SLC16A3 LOC105376790 MYADML2 NARF FAAP100 AATK-AS1 PCYT2 LOC100130370 WDR45B LRRC45 LOC101929552 OXLD1 OGFOD3 FN3K MIR3186 FSCN2 LOC105371925 MAFG PDE6G MIR6786 SECTM1 P4HB MCRIP1 TSPAN10 HGS LINC00482 ASPSCR1 SLC25A10 FASN DUS1L MIR6787 HEXDC CD7 ZNF750 AATK TMEM105 LOC105371944 MIR4740 C17orf89 GPS1 ARL16 MRPL12 ANAPC11 RAC3 MIR4525 MAFG-AS1 TEPSIN LOC101929511 B3GNTL1 RAB40B GCGR LOC105376791 RFNG STRA13 ACTG1 BAHCC1 ALYREF NPB FN3KRP PPP1R27 CCDC57 CCDC137 NOTUM PYCR1 SLC38A10 UTS2R DCXR CEP131
nsv470620	Chr.17:81516973 - 82064485 on Build GRCh38	Loss	DUS1L NPLOC4 ARHGDIA SIRT7 GPS1 MYADML2 ARL16 MRPL12 ANAPC11 RAC3 FAAP100 PCYT2 MAFG-AS1 LRRC45 OXLD1 GCGR FSCN2 RFNG MAFG PDE6G STRA13 MIR6786 ALYREF P4HB NPB PPP1R27 CCDC137 MCRIP1 TSPAN10 NOTUM PYCR1 HGS DCXR ASPSCR1 SLC25A10
nsv952390	Chr.17:81637175 - 81860124 on Build GRCh38	Deletion	OXLD1 GCGR PDE6G MIR6786 P4HB PPP1R27 CCDC137 ARL16 MRPL12 MCRIP1 TSPAN10 HGS SLC25A10

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein targeting to lysosome
autophagy
signal transduction
negative regulation of cell proliferation
membrane invagination
positive regulation of gene expression
endosomal transport
multivesicular body assembly
negative regulation of epidermal growth factor receptor signaling pathway
regulation of protein catabolic process
regulation of MAP kinase activity
negative regulation of JAK-STAT cascade
protein localization to membrane
positive regulation of exosomal secretion

Function(s)

protein binding
protein domain specific binding
metal ion binding