Hs02277060_cn

• Gene Symbol: LTK
• Assay Reference Genome Location: Chr.15:41503785 on build GRCh38
• Cytoband: 15q15.1

Target Gene Details

• Entrez Gene ID: 4058
• Gene Name: leukocyte receptor tyrosine kinase
• Gene Aliases: TYK1
• Location: Chr.15:41503639-41513887 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LTK	NM_001135685.1	18	2594	NP_001129157.1
	NM_002344.5	20	2984	NP_002335.2
	NM_206961.3	19	2801	NP_996844.1
	XM_017022181.1	20	3047	XP_016877670.1
	BC045607.1	18	3301	AAH45607.1
	BX329448.2	1	133
	CA394397.1	1	425
	D16105.1	20	2903	BAA03679.1
	X60702.1	19	2793	CAA43113.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv471241	Chr.15:41491616 - 41528002 on Build GRCh38	Loss	ITPKA LTK RPAP1
esv33378	Chr.15:41494307 - 41513562 on Build GRCh38	Gain	ITPKA LTK
nsv524476	Chr.15:41397034 - 41528002 on Build GRCh38	Loss	ITPKA RTF1 LTK RPAP1 NDUFAF1
nsv569233	Chr.15:41492611 - 41513039 on Build GRCh38	Loss	ITPKA LTK

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

protein phosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell proliferation
positive regulation of cardiac muscle cell apoptotic process
positive regulation of neuron projection development
phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
negative regulation of apoptotic process
cellular response to retinoic acid

Function(s)

protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding