Hs02318686_cn

• Gene Symbol: POLR3C
• Assay Reference Genome Location: Chr.1:145839923 on build GRCh38
• Cytoband: 1q21.1

Target Gene Details

• Entrez Gene ID: 10623
• Gene Name: RNA polymerase III subunit C
• Gene Aliases: RPC3, RPC62
• Location: Chr.1:145823183-145844402 on Build GRCh38
• Assay Gene Location: Within Exon 14

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
POLR3C	NM_001303456.1	12	1378	NP_001290385.1
	NM_006468.7	12	1576	NP_006459.3
	XM_005272927.3	13	2349	XP_005272984.1
	XM_005272928.3	13	1265	XP_005272985.1
	AK223413.1	12	1339	BAD97133.1
	AY091463.1	11	1273	AAM12033.1
	BC002586.1	12	1425	AAH02586.1
	BC004424.1			AAH04424.1
	U93867.1	12	1406	AAB63675.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1005055	Chr.1:145642988 - 148991068 on Build GRCh38	Loss	POLR3C NUDT17 LOC728989 LOC100505824 MIR6736 RNVU1-3 NBPF10 LOC284561 LINC01138 FMO5 LOC105371242 LOC105371226 ANKRD35 TXNIP CD160 RNU1-13P POLR3GL NOTCH2NL LOC101927468 GJA8 NUDT4P2 NBPF12 GPR89B LOC101928979 LOC100996763 ACP6 GJA5 RNVU1-8 NUDT4P1 CH17-408M7.1 HYDIN2 GPR89A PPIAL4G RNVU1-7 ITGA10 LIX1L NBPF14 RBM8A PDZK1P1 MIR6077 ANKRD34A PRKAB2 LOC100996517 CHD1L RNF115 PDZK1 RNVU1-1 LOC100132057 HFE2 PDIA3P1 BCL9 PEX11B MIR5087 RNVU1-6 PIAS3 NBPF11 GNRHR2 NBPF13P LINC00624 PDE4DIP
esv3587420	Chr.1:145824369 - 145905171 on Build GRCh38	Gain	POLR3C NUDT17 PIAS3 MIR6736 ITGA10 ANKRD35
nsv831381	Chr.1:145784568 - 145960930 on Build GRCh38	Gain	POLR3C NUDT17 RNF115 POLR3GL MIR6736 ITGA10 PEX11B LIX1L RBM8A PIAS3 GNRHR2 ANKRD35 ANKRD34A
esv3572008	Chr.1:145837994 - 145846568 on Build GRCh38	Gain	POLR3C NUDT17

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-directed RNA polymerase, RNA metabolism protein, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

regulation of transcription from RNA polymerase III promoter
transcription from RNA polymerase III promoter
positive regulation of type I interferon production
positive regulation of interferon-beta production
innate immune response
positive regulation of innate immune response
defense response to virus

Function(s)

RNA polymerase III activity
DNA binding
DNA-directed RNA polymerase activity
protein binding