Hs02320602_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67174319 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001185057.2	2	352	NP_001171986.1
	NM_001276307.1	4	376	NP_001263236.1
	NM_001276309.1	2	236	NP_001263238.1
	NM_001276311.1			NP_001263240.1
	NM_001276312.1	4	727	NP_001263241.1
	NM_001276319.1	4	727	NP_001263248.1
	NM_003946.6	2	352	NP_003937.1
	XM_005256217.2	2	989	XP_005256274.1
	XM_005256219.3			XP_005256276.1
	XM_011523424.2	3	832	XP_011521726.1
	XM_017023843.1	2	989	XP_016879332.1
	AF043244.1	2	269	AAC34993.1
	AF064599.1	2	203	AAC18593.1
	AF064600.1	2	227	AAC18594.1
	AK294145.1	4	692
	AK314899.1	2	257
	BC012798.2	2	238	AAH12798.1
	BP215200.1	2	193
	BQ685512.1	2	352
	BT020158.1	1	150	AAV38960.1
	CB959673.1	4	403

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	MIR328 C16orf86 SLC12A4 FAM65A TRADD CTRL DUS2 LOC105369155 FHOD1 CARMIL2 KIAA0895L NRN1L AGRP PSMB10 E2F4 EDC4 SLC9A5 LOC107984813 PLEKHG4 TSNAXIP1 LOC100505942 LRRC36 FBXL8 RANBP10 TMEM208 DPEP2 ZDHHC1 LOC100131303 PSKH1 EXOC3L1 GFOD2 TPPP3 ACD LRRC29 PARD6A DDX28 THAP11 HSD11B2 ENKD1 NOL3 NUTF2 HSF4 ATP6V0D1 ELMO3 DPEP3 CTCF KCTD19 CENPT LCAT
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	TMEM208 FHOD1 B3GNT9 NOL3 HSF4 ELMO3 MIR328 KIAA0895L EXOC3L1 E2F4 TRADD C16orf70 LRRC29 LOC105369155 FBXL8
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	TMEM208 FHOD1 B3GNT9 NOL3 HSF4 ELMO3 MIR328 KIAA0895L EXOC3L1 E2F4 SLC9A5 TRADD C16orf70 LRRC29 PLEKHG4 LOC105369155 FBXL8
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	NOL3 HSF4 ELMO3 MIR328 KIAA0895L LRRC29 EXOC3L1 LOC105369155 E2F4 FBXL8
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	MIR328 C16orf86 SLC12A4 FAM65A TRADD C16orf70 CTRL DUS2 LOC105369155 FHOD1 CARMIL2 KIAA0895L NRN1L AGRP PSMB10 E2F4 EDC4 SLC9A5 LOC107984813 PLEKHG4 TSNAXIP1 LOC100505942 LRRC36 FBXL8 RANBP10 TMEM208 DPEP2 B3GNT9 ZDHHC1 LOC100131303 PSKH1 EXOC3L1 GFOD2 TPPP3 ACD LRRC29 PARD6A DDX28 THAP11 HSD11B2 ENKD1 NOL3 NUTF2 HSF4 ATP6V0D1 ELMO3 DPEP3 CTCF KCTD19 CENPT LCAT
nsv471092	Chr.16:67174030 - 67518392 on Build GRCh38	Gain	TMEM208 FHOD1 HSD11B2 NOL3 ATP6V0D1 ELMO3 ZDHHC1 MIR328 KIAA0895L AGRP EXOC3L1 E2F4 SLC9A5 KCTD19 TPPP3 LRRC29 PLEKHG4 LOC105369155 LOC100505942 LRRC36

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding