Hs02566902_cn

• Gene Symbol: THRB
• Assay Reference Genome Location: Chr.3:24118816 on build GRCh38
• Cytoband: 3p24.2

Target Gene Details

• Entrez Gene ID: 7068
• Gene Name: thyroid hormone receptor beta
• Gene Aliases: C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
• Location: Chr.3:24117153-24495281 on Build GRCh38
• Assay Gene Location: Within Exon 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
THRB	NM_000461.4	10	5739	NP_000452.2
	NM_001128176.2	11	5850	NP_001121648.1
	NM_001128177.1	11	5876	NP_001121649.1
	NM_001252634.1	12	5974	NP_001239563.1
	XM_006713317.3	11	6090	XP_006713380.1
	AK096885.1	1	963
	AK098084.1	1	2039
	GQ869477.1	1	4068
	GQ869478.1	2	3945

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv834639	Chr.3:23995622 - 24192434 on Build GRCh38	Gain	THRB LOC101927854 LINC00691

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor, DNA-binding transcription factor, zinc finger transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
sensory perception of sound
negative regulation of female receptivity
regulation of heart contraction
female courtship behavior
organ morphogenesis
intracellular receptor signaling pathway
steroid hormone mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
Type I pneumocyte differentiation

Function(s)

DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription corepressor activity
thyroid hormone receptor activity
protein binding
zinc ion binding
enzyme binding
chromatin DNA binding
sequence-specific DNA binding
thyroid hormone binding