Hs02589867_cn

• Gene Symbol: CBFA2T3
• Assay Reference Genome Location: Chr.16:88879244 on build GRCh38
• Cytoband: 16q24.3

Target Gene Details

• Entrez Gene ID: 863
• Gene Name: CBFA2/RUNX1 translocation partner 3
• Gene Aliases: ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4
• Location: Chr.16:88874855-88977198 on Build GRCh38
• Assay Gene Location: Overlaps Intron 13 - Exon 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CBFA2T3	NM_005187.5			NP_005178.4
	NM_175931.2			NP_787127.1
	XM_005256323.4			XP_005256380.1
	XM_011523419.2			XP_011521721.1
	AB010419.1			BAA29061.1
	AB010420.1			BAA29062.1
	AK090985.1
	AK097904.1
	AK314766.1
	BC047019.1
	BC062624.1			AAH62624.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv37n68	Chr.16:88767460 - 88944903 on Build GRCh38	Loss	LOC107987238 LOC100129697 CDT1 TRAPPC2L APRT PABPN1L PIEZO1 CBFA2T3 GALNS LOC105371409 LOC101927793
nsv1063024	Chr.16:88707330 - 89238482 on Build GRCh38	Gain	LINC00304 LOC100289580 ACSF3 LOC400558 TRAPPC2L APRT PABPN1L CDH15 LOC105371409 MIR4722 ZNF778 LOC107987238 LOC100129697 CDT1 LOC339059 PIEZO1 CBFA2T3 SLC22A31 GALNS CTU2 LOC101927793
nsv1928	Chr.16:88865211 - 88897277 on Build GRCh38	Insertion	PABPN1L CBFA2T3 LOC101927793
nsv471115	Chr.16:88801844 - 89197442 on Build GRCh38	Loss	LINC00304 ACSF3 LOC400558 TRAPPC2L APRT PABPN1L CDH15 LOC105371409 LOC107987238 LOC100129697 CDT1 CBFA2T3 SLC22A31 GALNS LOC101927793
nsv573674	Chr.16:88738775 - 89325907 on Build GRCh38	Gain	LINC00304 LOC100289580 ACSF3 LOC400558 TRAPPC2L APRT PABPN1L CDH15 LOC105371409 ZNF778 LOC107987238 LOC100129697 CDT1 LOC339059 LOC100287036 ANKRD11 PIEZO1 CBFA2T3 SLC22A31 GALNS LOC105371414 LOC101927793
esv3639555	Chr.16:88745961 - 88899576 on Build GRCh38	Gain	LOC107987238 CDT1 TRAPPC2L APRT PABPN1L PIEZO1 CBFA2T3 GALNS LOC101927793
nsv521217	Chr.16:88805821 - 89174375 on Build GRCh38	Loss	LINC00304 ACSF3 LOC400558 TRAPPC2L APRT PABPN1L CDH15 LOC105371409 LOC107987238 LOC100129697 CDT1 CBFA2T3 GALNS LOC101927793
nsv952071	Chr.16:88790893 - 89019992 on Build GRCh38	Deletion	LOC107987238 LOC100129697 CDT1 TRAPPC2L APRT PABPN1L CBFA2T3 GALNS LOC105371409 LOC101927793
nsv482951	Chr.16:88633593 - 90228345 on Build GRCh38	Loss	DEF8 VPS9D1-AS1 ACSF3 TRAPPC2L PABPN1L CDH15 SNAI3 LOC105371409 SNAI3-AS1 LOC100129697 IL17C DPEP1 LOC339059 PIEZO1 CBFA2T3 SLC22A31 LOC105371419 LOC100289580 APRT LOC101927817 CDK10 MIR4722 ZNF778 URAHP TUBB3 TUBB8P7 SPIRE2 CDT1 LOC100287036 SPATA33 DBNDD1 GAS8 RPL13 ZNF276 TCF25 GAS8-AS1 AFG3L1P CENPBD1 SNORD68 LOC107987238 FAM157C CPNE7 RNF166 LOC101927793 LINC00304 VPS9D1 LOC400558 LOC107984817 CYBA ANKRD11 SPG7 MC1R FANCA SPATA2L MVD GALNS CTU2 CHMP1A LOC105371414 PRDM7
esv3639561	Chr.16:88837996 - 88882065 on Build GRCh38	Gain	TRAPPC2L PABPN1L CBFA2T3 GALNS
dgv3065n100	Chr.16:88711587 - 88927172 on Build GRCh38	Gain	LOC100289580 TRAPPC2L APRT PABPN1L MIR4722 LOC107987238 CDT1 LOC339059 PIEZO1 CBFA2T3 GALNS CTU2 LOC101927793

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transcription cofactor

Gene Ontology Categories:

Process(es)

response to hypoxia
transcription, DNA-templated
cell proliferation
negative regulation of cell proliferation
granulocyte differentiation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
regulation of aerobic respiration

Function(s)

transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
metal ion binding