Hs02589867_cn

• Gene Symbol: CBFA2T3
• Assay Reference Genome Location: Chr.16:88879244 on build GRCh38
• Cytoband: 16q24.3

Target Gene Details

• Entrez Gene ID: 863
• Gene Name: CBFA2/RUNX1 translocation partner 3
• Gene Aliases: ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4
• Location: Chr.16:88874855-88977198 on Build GRCh38
• Assay Gene Location: Overlaps Intron 13 - Exon 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CBFA2T3	NM_005187.5			NP_005178.4
	NM_175931.2			NP_787127.1
	XM_005256323.4			XP_005256380.1
	XM_011523419.2			XP_011521721.1
	AB010419.1			BAA29061.1
	AB010420.1			BAA29062.1
	AK090985.1
	AK097904.1
	AK314766.1
	BC047019.1
	BC062624.1			AAH62624.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv37n68	Chr.16:88767460 - 88944903 on Build GRCh38	Loss	PABPN1L TRAPPC2L LOC105371409 GALNS APRT PIEZO1 LOC101927793 CDT1 LOC100129697 CBFA2T3 LOC107987238
nsv1063024	Chr.16:88707330 - 89238482 on Build GRCh38	Gain	SLC22A31 LOC105371409 CDH15 LOC400558 LOC339059 APRT PIEZO1 LOC101927793 ZNF778 CDT1 LOC100129697 PABPN1L LOC100289580 MIR4722 TRAPPC2L ACSF3 LINC00304 GALNS CTU2 CBFA2T3 LOC107987238
nsv1928	Chr.16:88865211 - 88897277 on Build GRCh38	Insertion	PABPN1L LOC101927793 CBFA2T3
nsv471115	Chr.16:88801844 - 89197442 on Build GRCh38	Loss	SLC22A31 LOC105371409 CDH15 LOC400558 APRT LOC101927793 CDT1 LOC100129697 PABPN1L TRAPPC2L ACSF3 LINC00304 GALNS CBFA2T3 LOC107987238
nsv573674	Chr.16:88738775 - 89325907 on Build GRCh38	Gain	SLC22A31 LOC105371409 CDH15 LOC400558 LOC339059 APRT PIEZO1 LOC101927793 ZNF778 CDT1 ANKRD11 LOC100129697 PABPN1L LOC100289580 TRAPPC2L ACSF3 LINC00304 LOC105371414 GALNS LOC100287036 CBFA2T3 LOC107987238
esv3639555	Chr.16:88745961 - 88899576 on Build GRCh38	Gain	PABPN1L TRAPPC2L GALNS APRT PIEZO1 LOC101927793 CDT1 CBFA2T3 LOC107987238
nsv952071	Chr.16:88790893 - 89019992 on Build GRCh38	Deletion	PABPN1L TRAPPC2L LOC105371409 GALNS APRT LOC101927793 CDT1 LOC100129697 CBFA2T3 LOC107987238
nsv521217	Chr.16:88805821 - 89174375 on Build GRCh38	Loss	LOC105371409 CDH15 LOC400558 APRT LOC101927793 CDT1 LOC100129697 PABPN1L TRAPPC2L ACSF3 LINC00304 GALNS CBFA2T3 LOC107987238
nsv482951	Chr.16:88633593 - 90228345 on Build GRCh38	Loss	IL17C LOC105371409 CYBA LOC400558 LOC339059 CENPBD1 DPEP1 LOC101927793 LOC100129697 LOC105371419 RPL13 PRDM7 TUBB8P7 LOC100289580 FANCA CDK10 ACSF3 LINC00304 LOC105371414 TUBB3 FAM157C CBFA2T3 CPNE7 AFG3L1P CHMP1A DEF8 RNF166 APRT PIEZO1 GAS8 MIR4722 TRAPPC2L SNAI3 SNORD68 VPS9D1-AS1 URAHP SLC22A31 DBNDD1 GAS8-AS1 GALNS LOC101927817 SPG7 SPATA33 SPATA2L SNAI3-AS1 CDH15 VPS9D1 LOC107984817 TCF25 ZNF778 CDT1 MC1R ANKRD11 MVD PABPN1L LOC100287036 SPIRE2 CTU2 ZNF276 LOC107987238
esv3639561	Chr.16:88837996 - 88882065 on Build GRCh38	Gain	PABPN1L TRAPPC2L GALNS CBFA2T3
nsv1061256	Chr.16:88711587 - 89013365 on Build GRCh38	Gain	LOC105371409 LOC339059 APRT PIEZO1 LOC101927793 CDT1 LOC100129697 PABPN1L LOC100289580 MIR4722 TRAPPC2L GALNS CTU2 CBFA2T3 LOC107987238

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transcription cofactor

Gene Ontology Categories:

Process(es)

response to hypoxia
transcription, DNA-templated
cell proliferation
negative regulation of cell proliferation
granulocyte differentiation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
regulation of aerobic respiration

Function(s)

transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
metal ion binding