Hs02647764_cn

• Gene Symbol: BAD
• Assay Reference Genome Location: Chr.11:64284478 on build GRCh38
• Cytoband: 11q13.1

Target Gene Details

• Entrez Gene ID: 572
• Gene Name: BCL2 associated agonist of cell death
• Gene Aliases: BBC2, BCL2L8
• Location: Chr.11:64269828-64284704 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAD	NM_004322.3	1	227	NP_004313.1
	NM_032989.2			NP_116784.1
	AK291863.1
	AK303051.1
	AK309150.1
	BC095431.1			AAH95431.1
	BE255791.1	1	132
	BG435829.1	1	163
	BG748336.1

Target Gene Details

• Entrez Gene ID: 56834
• Gene Name: G protein-coupled receptor 137
• Gene Aliases: C11orf4, GPR137A, TM7SF1L1
• Location: Chr.11:64270337-64289500 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
GPR137	NM_001170726.1			NP_001164197.1
	XM_011545168.2			XP_011543470.1
	XM_011545170.2			XP_011543472.1
	XM_011545171.2			XP_011543473.1
	XM_011545172.2			XP_011543474.1
	XM_017018016.1			XP_016873505.1
	AK300209.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951010	Chr.11:63942829 - 64352128 on Build GRCh38	Deletion	LOC105369340 VEGFB PLCB3 TRPT1 GPR137 DNAJC4 TEX40 KCNK4-TEX40 COX8A FERMT3 PPP1R14B NAA40 MACROD1 CCDC88B MIR7155 FKBP2 ESRRA FLRT1 STIP1 PRDX5 TRMT112 KCNK4 NUDT22 OTUB1 BAD
dgv1963n54	Chr.11:64174262 - 64329761 on Build GRCh38	Loss	LOC105369340 FERMT3 PPP1R14B VEGFB PLCB3 FKBP2 ESRRA TRPT1 STIP1 PRDX5 GPR137 TRMT112 DNAJC4 KCNK4 TEX40 KCNK4-TEX40 NUDT22 BAD
nsv832186	Chr.11:64204788 - 64402587 on Build GRCh38	Loss	LOC105369340 FERMT3 PPP1R14B VEGFB PLCB3 CCDC88B MIR7155 FKBP2 ESRRA TRPT1 PRDX5 GPR137 TRMT112 DNAJC4 KCNK4 TEX40 KCNK4-TEX40 NUDT22 RPS6KA4 MIR1237 BAD
nsv469961	Chr.11:64055468 - 64318495 on Build GRCh38	Loss	LOC105369340 FERMT3 PPP1R14B VEGFB PLCB3 MACROD1 FKBP2 ESRRA TRPT1 FLRT1 STIP1 PRDX5 GPR137 TRMT112 DNAJC4 KCNK4 TEX40 KCNK4-TEX40 NUDT22 BAD
nsv357	Chr.11:64284335 - 64308789 on Build GRCh38	Insertion	KCNK4 TEX40 KCNK4-TEX40 ESRRA GPR137 BAD

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

release of cytochrome c from mitochondria
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
glucose catabolic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
spermatogenesis
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
response to glucose
positive regulation of autophagy
positive regulation of mitochondrial membrane potential
suppression by virus of host apoptotic process
cytokine-mediated signaling pathway
cerebral cortex development
positive regulation of insulin secretion
response to estradiol
response to progesterone
positive regulation of glucokinase activity
response to testosterone
response to oleic acid
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to drug
response to hydrogen peroxide
glucose homeostasis
positive regulation of apoptotic process
response to amino acid
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
type B pancreatic cell proliferation
response to ethanol
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of proteolysis
negative regulation of cytolysis
ADP metabolic process
ATP metabolic process
regulation of mitochondrial membrane permeability
pore complex assembly
positive regulation of epithelial cell proliferation
response to glucocorticoid
response to calcium ion
positive regulation of apoptotic process by virus
cellular process regulating host cell cycle in response to virus
cellular response to chromate
cellular response to mechanical stimulus
cellular response to nicotine
cellular response to lipid
cellular response to hypoxia
positive regulation of release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
intrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of neuron death
positive regulation of type B pancreatic cell development
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

protein binding
phospholipid binding
lipid binding
cysteine-type endopeptidase activator activity involved in apoptotic process
protein kinase binding
protein phosphatase 2B binding
protein kinase B binding
protein heterodimerization activity
14-3-3 protein binding