Hs02658328_cn

• Gene Symbol: STAT3
• Assay Reference Genome Location: Chr.17:42313288 on build GRCh38
• Cytoband: 17q21.2

Target Gene Details

• Entrez Gene ID: 6774
• Gene Name: signal transducer and activator of transcription 3
• Gene Aliases: ADMIO, ADMIO1, APRF, HIES
• Location: Chr.17:42313324-42388505 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 24

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STAT3	XM_011525145.2			XP_011523447.1
	XM_011525146.2			XP_011523448.1
	XM_017024973.1			XP_016880462.1
	AK024535.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833449	Chr.17:42274854 - 42421081 on Build GRCh38	Loss	STAT5B PTRF STAT5A STAT3
nsv1056904	Chr.17:42025823 - 42363204 on Build GRCh38	Gain	HSPB9 KAT2A STAT5B RAB5C DHX58 KCNH4 GHDC ZNF385C HCRT STAT5A STAT3

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
temperature homeostasis
eye photoreceptor cell differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein import into nucleus
movement of cell or subcellular component
acute-phase response
signal transduction
JAK-STAT cascade
nervous system development
aging
cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of hydrogen peroxide biosynthetic process
viral process
phosphorylation
cytokine-mediated signaling pathway
sexual reproduction
intracellular receptor signaling pathway
response to estradiol
cellular response to hormone stimulus
leptin-mediated signaling pathway
somatic stem cell population maintenance
miRNA mediated inhibition of translation
regulation of multicellular organism growth
response to drug
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
eating behavior
negative regulation of apoptotic process
cellular response to leptin stimulus
response to leptin
response to ethanol
positive regulation of Notch signaling pathway
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of mitochondrial membrane permeability
astrocyte differentiation
regulation of cell cycle
radial glial cell differentiation
regulation of feeding behavior
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
interleukin-6-mediated signaling pathway
cellular response to organic cyclic compound
energy homeostasis
negative regulation of neuron death
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of metalloendopeptidase activity
positive regulation of gene silencing by miRNA
positive regulation of ATP biosynthetic process
negative regulation of neuron migration

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
protein phosphatase binding
chromatin DNA binding
CCR5 chemokine receptor binding
glucocorticoid receptor binding
identical protein binding
transcription regulatory region DNA binding
protein dimerization activity