Hs02773218_cn

• Gene Symbol: ADORA2A
• Assay Reference Genome Location: Chr.22:24442143 on build GRCh38
• Cytoband: 22q11.23

Target Gene Details

• Entrez Gene ID: 135
• Gene Name: adenosine A2a receptor
• Gene Aliases: A2aR, ADORA2, RDC8
• Location: Chr.22:24423597-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A	NM_000675.5	3	2352	NP_000666.2
	NM_001278497.1	4	2523	NP_001265426.1
	NM_001278498.1	3	2417	NP_001265427.1
	NM_001278499.1	3	2332	NP_001265428.1
	NM_001278500.1	3	2199	NP_001265429.1
	NR_103543.1	2	1746
	NR_103544.1	2	1726
	AK123058.1	4	2262
	BC013780.1	3	2279	AAH13780.1
	CA307692.1	1	232
	HY249059.1	1	49
	M97370.1	2	2154	AAA58356.1

Target Gene Details

• Entrez Gene ID: 646023
• Gene Name: ADORA2A antisense RNA 1
• Gene Aliases: C22orf45
• Location: Chr.22:24429206-24495074 on Build GRCh38
• Assay Gene Location: Overlaps Intron 5 - Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A-AS1	NR_028483.2
	NR_028484.2
	DB449907.2

Target Gene Details

• Entrez Gene ID: 101730217
• Gene Name: SPECC1L-ADORA2A readthrough (NMD candidate)
• Gene Aliases: -
• Location: Chr.22:24270817-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SPECC1L-ADORA2A	NR_103546.1	20	6072
	AB209022.1	20	5990	BAD92259.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2724068	Chr.22:24288741 - 24669870 on Build GRCh38	Deletion	POM121L10P UPB1 LRRC75B GUCD1 BCRP3 GGT1 SPECC1L SNRPD3 ADORA2A-AS1 SPECC1L-ADORA2A ADORA2A
dgv8039n54	Chr.22:23323169 - 24601506 on Build GRCh38	Gain	UPB1 CHCHD10 GSTT2 CES5AP1 MIF SLC2A11 SPECC1L IGLL1 C22orf15 MMP11 ADORA2A-AS1 ZDHHC8P1 SPECC1L-ADORA2A ADORA2A LOC107985555 GUCD1 LOC107985559 GUSBP11 SMARCB1 POM121L9P LOC388882 PCAT14 GGT5 DRICH1 MIF-AS1 SUSD2 ZNF70 GSTTP1 LRRC75B GSTT2B RGL4 GGT1 LOC100652871 CABIN1 DDTL SNRPD3 DDT LOC101929374 DERL3 VPREB3
nsv1057819	Chr.22:24290518 - 24624081 on Build GRCh38	Gain	UPB1 LRRC75B GUCD1 GGT1 SPECC1L SNRPD3 ADORA2A-AS1 SPECC1L-ADORA2A ADORA2A
nsv526567	Chr.22:23348138 - 24600663 on Build GRCh38	Gain	UPB1 CHCHD10 GSTT2 CES5AP1 MIF SLC2A11 SPECC1L IGLL1 C22orf15 MMP11 ADORA2A-AS1 ZDHHC8P1 SPECC1L-ADORA2A ADORA2A LOC107985555 GUCD1 LOC107985559 GUSBP11 SMARCB1 POM121L9P LOC388882 PCAT14 GGT5 DRICH1 MIF-AS1 SUSD2 ZNF70 GSTTP1 LRRC75B GSTT2B RGL4 GGT1 LOC100652871 CABIN1 DDTL SNRPD3 DDT LOC101929374 DERL3 VPREB3
esv2724041	Chr.22:23315914 - 24669376 on Build GRCh38	Deletion	UPB1 CHCHD10 GSTT2 CES5AP1 MIF SLC2A11 SPECC1L IGLL1 C22orf15 MMP11 ADORA2A-AS1 ZDHHC8P1 SPECC1L-ADORA2A ADORA2A LOC107985555 GUCD1 BCRP3 LOC107985559 GUSBP11 SMARCB1 POM121L9P LOC388882 PCAT14 GGT5 DRICH1 MIF-AS1 SUSD2 BCR ZNF70 POM121L10P GSTTP1 LRRC75B GSTT2B RGL4 GGT1 LOC100652871 CABIN1 DDTL SNRPD3 DDT LOC101929374 DERL3 VPREB3
nsv1055830	Chr.22:24005071 - 24643213 on Build GRCh38	Gain	UPB1 GGT5 SPECC1L ADORA2A-AS1 SUSD2 SPECC1L-ADORA2A ADORA2A GSTTP1 LRRC75B GUCD1 BCRP3 GGT1 CABIN1 POM121L9P SNRPD3
esv3893463	Chr.22:24009046 - 24601506 on Build GRCh38	Gain	UPB1 GGT5 SPECC1L ADORA2A-AS1 SUSD2 SPECC1L-ADORA2A ADORA2A LRRC75B GUCD1 GGT1 CABIN1 POM121L9P SNRPD3
dgv4528n100	Chr.22:23322244 - 24682765 on Build GRCh38	Gain	UPB1 CHCHD10 GSTT2 CES5AP1 MIF SLC2A11 SPECC1L IGLL1 C22orf15 MMP11 ADORA2A-AS1 ZDHHC8P1 SPECC1L-ADORA2A ADORA2A LOC107985555 GUCD1 BCRP3 LOC107985559 GUSBP11 SMARCB1 POM121L9P LOC388882 PCAT14 GGT5 DRICH1 MIF-AS1 SUSD2 ZNF70 POM121L10P GSTTP1 LRRC75B GSTT2B RGL4 GGT1 LOC100652871 CABIN1 DDTL SNRPD3 DDT LOC101929374 DERL3 VPREB3
nsv588744	Chr.22:24285587 - 24617379 on Build GRCh38	Gain	UPB1 LRRC75B GUCD1 GGT1 SPECC1L SNRPD3 ADORA2A-AS1 SPECC1L-ADORA2A ADORA2A
nsv9884	Chr.22:24415625 - 24662249 on Build GRCh38	Gain+Loss	POM121L10P UPB1 LRRC75B GUCD1 BCRP3 GGT1 SPECC1L SNRPD3 ADORA2A-AS1 SPECC1L-ADORA2A ADORA2A
esv3575443	Chr.22:23348201 - 24670505 on Build GRCh38	Gain	UPB1 CHCHD10 GSTT2 CES5AP1 MIF SLC2A11 SPECC1L IGLL1 C22orf15 MMP11 ADORA2A-AS1 ZDHHC8P1 SPECC1L-ADORA2A ADORA2A LOC107985555 GUCD1 BCRP3 LOC107985559 GUSBP11 SMARCB1 POM121L9P LOC388882 PCAT14 GGT5 DRICH1 MIF-AS1 SUSD2 ZNF70 POM121L10P GSTTP1 LRRC75B GSTT2B RGL4 GGT1 LOC100652871 CABIN1 DDTL SNRPD3 DDT LOC101929374 DERL3 VPREB3
nsv834160	Chr.22:24329972 - 24507687 on Build GRCh38	Gain	UPB1 SPECC1L ADORA2A-AS1 SPECC1L-ADORA2A ADORA2A

More Information

• Set Membership: Intragenic, Exonic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

adenosine receptor signaling pathway
cAMP biosynthetic process
phagocytosis
apoptotic process
inflammatory response
cellular defense response
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell-cell signaling
central nervous system development
blood coagulation
sensory perception
blood circulation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
cellular protein metabolic process

Function(s)

G-protein coupled adenosine receptor activity
protein binding
enzyme binding
identical protein binding