Hs02915827_cn

• Gene Symbol: CYFIP1
• Assay Reference Genome Location: Chr.15:22873709 on build GRCh38
• Cytoband: 15q11.2

Target Gene Details

• Entrez Gene ID: 23191
• Gene Name: cytoplasmic FMR1 interacting protein 1
• Gene Aliases: P140SRA-1, SHYC, SRA-1, SRA1
• Location: Chr.15:22869465-22980906 on Build GRCh38
• Assay Gene Location: Overlaps Intron 30 - Exon 31

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CYFIP1	NM_001033028.1			NP_001028200.1
	NM_001287810.2			NP_001274739.1
	NM_001324119.1			NP_001311048.1
	NM_001324120.1			NP_001311049.1
	NM_001324122.1			NP_001311051.1
	NM_001324123.1			NP_001311052.1
	NM_001324124.1			NP_001311053.1
	NM_001324125.1			NP_001311054.1
	NM_001324126.1			NP_001311055.1
	NM_014608.4			NP_055423.1
	XM_011543873.2			XP_011542175.1
	XM_011543874.1			XP_011542176.1
	XM_011543876.2			XP_011542178.2
	XM_017022023.1			XP_016877512.1
	XM_017022024.1			XP_016877513.1
	AK125784.1
	AK125936.1
	AK127094.1			BAC86825.1
	AK291604.1
	AY763577.1			AAW51476.1
	AY763578.1			AAW51477.1
	AY763579.1			AAW51478.1
	AY763580.1			AAW51479.1
	BC001306.2			AAH01306.2
	BC005097.1			AAH05097.1
	D38549.1
	KJ534819.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv2404n100	Chr.15:22736803 - 23199681 on Build GRCh38	Gain	NIPA2 GOLGA8DP GOLGA6L1 TUBGCP5 LOC283683 CYFIP1 MIR4509-1 NIPA1
dgv287n27	Chr.15:22732985 - 23117883 on Build GRCh38	Gain	NIPA2 TUBGCP5 LOC283683 CYFIP1 NIPA1
nsv469615	Chr.15:22846234 - 22995927 on Build GRCh38	Loss	NIPA2 TUBGCP5 CYFIP1
dgv2407n100	Chr.15:22385562 - 23199681 on Build GRCh38	Gain+Loss	HERC2P2 GOLGA8DP CYFIP1 MIR4509-1 NIPA2 GOLGA6L1 GOLGA8EP GOLGA8IP TUBGCP5 GOLGA6L22 LOC283683 HERC2P7 WHAMMP3 NIPA1
dgv4320n54	Chr.15:22708781 - 23117883 on Build GRCh38	Gain	NIPA2 TUBGCP5 LOC283683 CYFIP1 NIPA1
esv3892604	Chr.15:22721590 - 23121326 on Build GRCh38	Gain+Loss	NIPA2 TUBGCP5 LOC283683 CYFIP1 NIPA1
nsv832926	Chr.15:22824508 - 22961816 on Build GRCh38	Gain+Loss	NIPA2 CYFIP1 NIPA1
esv3635807	Chr.15:22786232 - 23120073 on Build GRCh38	Gain	NIPA2 TUBGCP5 CYFIP1 NIPA1
nsv456636	Chr.15:22788625 - 22997016 on Build GRCh38	Loss	NIPA2 TUBGCP5 CYFIP1 NIPA1
dgv4319n54	Chr.15:22738859 - 23117883 on Build GRCh38	Gain+Loss	NIPA2 TUBGCP5 LOC283683 CYFIP1 NIPA1
nsv1040546	Chr.15:22455908 - 23121986 on Build GRCh38	Gain	NIPA2 HERC2P2 GOLGA8IP TUBGCP5 GOLGA6L22 LOC283683 HERC2P7 CYFIP1 WHAMMP3 NIPA1
dgv709e212	Chr.15:22581937 - 23102646 on Build GRCh38	Gain	NIPA2 HERC2P2 GOLGA8IP TUBGCP5 LOC283683 CYFIP1 WHAMMP3 NIPA1
esv3892626	Chr.15:22358243 - 23220738 on Build GRCh38	Gain+Loss	HERC2P2 GOLGA8DP CYFIP1 MIR4509-1 NIPA2 GOLGA6L1 GOLGA8EP GOLGA8IP TUBGCP5 GOLGA6L22 LOC283683 HERC2P7 WHAMMP3 NIPA1
dgv4318n54	Chr.15:22567965 - 23122763 on Build GRCh38	Gain	NIPA2 HERC2P2 GOLGA8IP TUBGCP5 LOC283683 CYFIP1 WHAMMP3 NIPA1
nsv568226	Chr.15:22850232 - 23121326 on Build GRCh38	Gain	NIPA2 TUBGCP5 CYFIP1
nsv469667	Chr.15:22720659 - 22890398 on Build GRCh38	Loss	NIPA2 LOC283683 CYFIP1 NIPA1
dgv2403n100	Chr.15:22572335 - 23226874 on Build GRCh38	Gain	NIPA2 HERC2P2 GOLGA8DP GOLGA6L1 GOLGA8IP TUBGCP5 LOC283683 CYFIP1 MIR4509-1 WHAMMP3 NIPA1
dgv4317n54	Chr.15:22770773 - 23122763 on Build GRCh38	Loss	NIPA2 TUBGCP5 LOC283683 CYFIP1 NIPA1
nsv471225	Chr.15:22645574 - 23117883 on Build GRCh38	Gain	NIPA2 TUBGCP5 LOC283683 CYFIP1 WHAMMP3 NIPA1
esv3635821	Chr.15:22818925 - 22904223 on Build GRCh38	Loss	NIPA2 CYFIP1 NIPA1
dgv2409n100	Chr.15:22590297 - 23121986 on Build GRCh38	Loss	NIPA2 HERC2P2 GOLGA8IP TUBGCP5 LOC283683 CYFIP1 WHAMMP3 NIPA1
dgv9n31	Chr.15:22787819 - 22878508 on Build GRCh38	Loss	NIPA2 CYFIP1 NIPA1
nsv437797	Chr.15:22856510 - 22939650 on Build GRCh38	Loss	NIPA2 CYFIP1
esv34463	Chr.15:22650812 - 23095232 on Build GRCh38	Gain	NIPA2 TUBGCP5 LOC283683 CYFIP1 WHAMMP3 NIPA1
nsv433429	Chr.15:22444191 - 23220738 on Build GRCh38	Gain	HERC2P2 GOLGA8DP CYFIP1 MIR4509-1 NIPA2 GOLGA6L1 GOLGA8IP TUBGCP5 GOLGA6L22 LOC283683 HERC2P7 WHAMMP3 NIPA1
nsv568235	Chr.15:22576506 - 23117883 on Build GRCh38	Loss	NIPA2 HERC2P2 GOLGA8IP TUBGCP5 LOC283683 CYFIP1 WHAMMP3 NIPA1
nsv442359	Chr.15:22777657 - 23191992 on Build GRCh38	Gain+Loss	NIPA2 GOLGA8DP GOLGA6L1 TUBGCP5 LOC283683 CYFIP1 NIPA1
nsv471376	Chr.15:22869466 - 22917313 on Build GRCh38	Loss	CYFIP1

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

regulation of cell shape
Rac protein signal transduction
lamellipodium assembly
ruffle organization
Fc-gamma receptor signaling pathway involved in phagocytosis
vascular endothelial growth factor receptor signaling pathway
axon extension
cognition
positive regulation of Arp2/3 complex-mediated actin nucleation

Function(s)

protein binding
protein complex binding
Rac GTPase binding
actin filament binding